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The Ohio State University MS Center Patient Questionnaire 1 PATIENT QUESTIONNAIRE Dr Kathleen Hawker MD Dr. D. Joanne Lynn MD Dr. Michael Race MD Dr. Lottie Rammstein MD THIS QUESTIONNAIRE MUST BE
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Hawker, I would welcome the opportunity to discuss the possibility of a future research project regarding pain control in my patients. I am an MD with over 30 years of experience in psychiatry and human and animal research. My clinical areas of specialty are in pain management as well as in sleep disorders, anxiety and depression. I would consider the role neurogenesis in pain control to be one of the top medical issues in my field. I have worked with animals in my research projects such as pigs, mice, rats, rabbits and hamsters. Furthermore, I think that this project would be exciting, and I could learn a lot from your clinical studies on mice and pigs. Furthermore, I have recently read your papers in which you describe a model that is based on the human neurogenic wound in which neurogenesis is inhibited. The neurogenic wound model involves the administration of a specific neurotoxin (i.e. anesthetic) in the absence of pain. My research on neurogenesis and pain was inspired by this study in my research laboratory. My research involved determining the effect of treatment with the neurotoxin ketamine on neurogenesis and the development of chronic pain in mice. The current experiments of mine involve measuring the rates of neurogenesis with and without the neurotoxin and evaluating the possible benefits and damages as observed by examining the rate of the generation and survival of new neurons. The neurogenic wound model is very exciting as there are numerous unanswered questions. In addition to the mechanisms of how the neurotoxin affects cells, do the effects follow the same process, or is the treatment more effective on particular subpopulations of cells. For these reasons, my research is in a very early phase. We are using two strains of mice; one strain is resistant to being anesthetized and one strain is vulnerable to being anesthetized, so that we could examine each strain independently. We have also started testing the effects of the neurotoxin on other cells that contribute to the wound healing process in other parts of the body. My research group has also looked at the impact of multiple insults including traumatic injury, metabolic stress, immune activation and age. Please feel free to contact me if you have any questions regarding this work. Thanks for your consideration of my study.

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