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Prognostic gene signatures for non-small-cell lung cancer Paul C. Outros, b,1, Suzanne K. Lava, b, Melania Pintle, Ni Limb, Frances A. Shepherd, d, Sandy D. Verb, e, Ming-Sound Saga, b, e, Linda Z.
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University of Toronto, Toronto, ON, Canada e-mail: Cairo.toshiuniv.ca Pre-publication history The following pre-publication history is complete and accurate to the best of our knowledge. The history is updated to include the latest publication. Published July 9, 2007, Revised November 11, 2007 © Copyright The Authors 2008.

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Prognostic gene signatures are used to predict the clinical outcome or prognosis of a patient based on the expression patterns of specific genes.
There is no specific requirement to file prognostic gene signatures. However, researchers and clinicians may develop and use these signatures in their studies or clinical practice.
Prognostic gene signatures are typically derived through the analysis of gene expression data using various bioinformatics and statistical methods.
The purpose of prognostic gene signatures is to provide prognostic or predictive information about the outcome or response to therapy for patients with a specific disease or condition.
The information reported on prognostic gene signatures may include the specific genes included in the signature, their expression levels, statistical measures of association with prognosis, and any validation or clinical evidence supporting their utility.
There is no specific deadline to file prognostic gene signatures as they are not required to be filed. However, if there are any regulatory or publication requirements, they should be adhered to.
There are no penalties for the late filing of prognostic gene signatures as they are not subject to specific filing deadlines or regulatory requirements.
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