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In the past three years, we have published an unprecedented number of papers which involve (not solely) C-terminal RNA and its regulation — such as C-terminal RNA binding sites in the mouse brain and in human fibroblasts (reviewed in [1]) — but our field has recently seen many studies showing no change in the C terminus of CCR7-binding genes between mouse and human lineage [2-7,9-12]. This finding may provide the first insight into functional conservation in regulatory motifs between mouse and human — but could also indicate that the structural, functional and regulatory differences observed between human and mouse in some regions of the genome have a direct evolutionary basis [6]. In this respect, the recent publication of a mouse CCR7 RNA transgene showed no detectable decrease in mRNA levels in vivo or in culture compared to the original transgene in both mouse and human [13]. However, this effect was abolished in the presence of the CCR7 promoter-inhibiting DNA methyltransferase methylBH4 (mDNABH4) construct, and the authors conclude that in vitro expression of the mDNABH4 construct is important for in vivo binding of the transgene [13]. In addition to these effects, the role of CCR7 mRNA is also being investigated in cancer [39], and in some other disease states such as diabetes [38,40-42].. To make your life as a coder, engineer or consultant easier, you should have access to your documents, memos, emails, notes, invoices, tasks etc. What's NEW Improved workflow (previously it was hard to find your documents, so we made it super easy) (previously it was hard to find your documents, so we made it super easy) Improved searching (better search results for your documents) (better search results for your documents) Advanced search options (Advanced search gives you great power, but you should not feel over-power just yet) (Advanced search gives you great power, but you should not feel over-power just yet) Many bug fixes Trial Version Download and try the demo version for 5 days for free. ‫ We do not provide any support, if you encounter any issue, contact us.. We've also made it easy to create templates, edit, sign, and store all of your documents online. Create, Sign, & Store Your Papers Online Start organizing and digitizing your documents the easy way with our robust PDF editor. With support for a variety of document formats, this handy software tools lets you: Use the standard keyboard shortcuts for your favorite document types Drag and drop your documents from one folder to another Export your documents in several formats to save time when reviewing drafts Get the most out of free online signature software: Get to know Signing Letter in detail Create templates for your most-used forms without worrying about retyping Story your signature and capture every keystroke needed for a signature Edit, sign, and store your signature online Easily make changes without printing and storing your document Use tools like drag-and-drop and document builder to help you with your documents Stirring the pot has never been easier, and Signing Letter provides tools to help you make good use of the paperless lifestyle. Signing Letter Plus has an unlimited license and includes most of the features listed above, but lets you organize and store your documents from your desktop and on the go, so you'll never go without it..