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Gene expression in eukaryotic cells is regulated by repressors as well as by transcriptional activators. Like their prokaryotic counterparts, eukaryotic repressors bind to specific DNA sequences and inhibit transcription. ... Other repressors compete with activators for binding to specific regulatory sequences.
However, unlike prokaryotic cells, the eukaryotic RNA polymerase requires other proteins, or transcription factors, to facilitate transcription initiation. Transcription factors are proteins that bind to the promoter sequence and other regulatory sequences to control the transcription of the target gene.
Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. ... Regulation of transcription is the most common form of gene control. The action of transcription factors allows for unique expression of each gene in different cell types and during development.
Prokaryotic transcription and translation occur simultaneously in the cytoplasm, and regulation occurs at the transcriptional level. Eukaryotic gene expression is regulated during transcription and RNA processing, which take place in the nucleus, and during protein translation, which takes place in the cytoplasm.
Gene regulation is the process of controlling which genes in a cell's DNA are expressed (used to make a functional product such as a protein). Different cells in a multicellular organism may express very different sets of genes, even though they contain the same DNA.
Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes. ... Other transcription factors bind to regulatory sequences, such as enhancer sequences, and can either stimulate or repress transcription of the related gene.
Regulatory landscape Transcriptional initiation, termination and regulation are mediated by DNA looping which brings together promoters, enhancers, transcription factors and RNA processing factors to accurately regulate gene expression. ... The configuration of the genome is essential for enhancer-promoter proximity.
General transcription factors are essential for any transcription for all genes while regulatory transcription factors regulate transcription of specific genes. ... General transcription factors only regulate the housekeeping genes while regulatory transcription factors control all the other genes.
Transcription factors are a very diverse family of proteins and generally function in multi-subunit protein complexes. They may bind directly to special promoter regions of DNA, which lie upstream of the coding region in a gene, or directly to the RNA polymerase molecule.
Gene regulation can occur at any point of the transcription-translation process, but most often occurs at the transcription level. Proteins that can be activated by other cells and signals from the environment are called transcription factors.
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