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This document reports on a study exploring the effects of exercise training on tumor vascularity and response to neoadjuvant therapy in operable breast cancer, including methodology, participant recruitment,
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How to fill out THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)
01
Begin by clearly stating the objectives of the study regarding the effects of exercise training.
02
Define the target population: patients with operable breast cancer undergoing neoadjuvant therapy.
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Detail the methodology for exercise training, including types, duration, and frequency.
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Explain how tumor vascularity will be assessed before and after the exercise intervention.
05
Outline the measures for evaluating the response to neoadjuvant therapy in relation to exercise.
06
Include a plan for data collection and statistical analysis.
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Discuss safety and ethical considerations, including informed consent.
Who needs THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)?
01
Patients diagnosed with operable breast cancer who are candidates for neoadjuvant therapy.
02
Oncologists and healthcare professionals looking for alternative treatment strategies.
03
Researchers interested in the interaction between exercise and cancer treatment outcomes.
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Institutions seeking to improve patient care through innovative therapeutic approaches.
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People Also Ask about
Can exercise shrink cancer tumors?
Those trials are ongoing and results should hopefully be published in the next five years. At MSK's Exercise Oncology Service, researchers found that exercising a mouse with cancer led to the cancer growing 30% slower. Exercise didn't stop cancer growth, but it did slow it down.
What is the response rate for neoadjuvant chemotherapy?
Background: Neoadjuvant chemotherapy (NCT), Triple-negative cancer (TNBC) including anthracyclines and taxanes for early stages of TNBC, allows to achieve pathological complete response (pCR) in 25-36% of patients.
What is the effect of exercise training on lean body mass in cancer patients a systematic review and meta analysis?
Results: Data from 17 studies involving 1743 cancer survivors were included in the meta-analysis. Overall, there was a significant benefit of exercise training compared with control on LBM (0.58 kg, 95% confidence interval = 0.27 to 0.88, P < 0.001).
How might the effects of exercise on tumour blood supply influence tumour progression and treatment?
Tumour blood vessels are structurally and functionally abnormal, resulting in areas of hypoxia and heterogeneous blood supply. Aerobic exercise may modulate tumour blood flow and normalise the tumour microenvironment to improve chemotherapy delivery.
How does neoadjuvant therapy respond to cancer?
Predictors of response to neoadjuvant chemotherapy This concept is the same in tumors as well as axillary lymph nodes. Studies have shown that the rate of response to therapy varies from 15% to 30% depending on the type of tumor and the type of chemotherapy used.
How does neoadjuvant chemotherapy affect cancer?
Neoadjuvant chemotherapy may be able to shrink a large tumor enough so a lumpectomy (plus radiation therapy) becomes an option instead of a mastectomy [11]. Neoadjuvant chemotherapy may also be given to people who have enlarged lymph nodes in the underarm area due to the spread of cancer to these lymph nodes.
What is a complete response to neoadjuvant chemotherapy?
This neoadjuvant chemotherapy (NAC) is intended to reduce the tumor load and may result in the pathological complete response (pCR), i.e., the absence of visible tumor cells in the surgery resections. Studies have shown that pCR is associated with event-free survival and recurrence-free survival [2].
What is neoadjuvant therapy response in cancer?
Predictors of response to neoadjuvant chemotherapy This concept is the same in tumors as well as axillary lymph nodes. Studies have shown that the rate of response to therapy varies from 15% to 30% depending on the type of tumor and the type of chemotherapy used.
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What is THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)?
The study investigates how exercise training impacts tumor vascularity and the effectiveness of neoadjuvant therapy in patients with operable breast cancer, aiming to determine potential benefits of physical activity on treatment outcomes.
Who is required to file THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)?
Researchers and clinical trial coordinators involved in the study of exercise training and its effects on breast cancer patients are required to file relevant documentation as part of the IDEA award application process.
How to fill out THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)?
To fill out the study forms, participants should provide detailed information about the study design, objectives, methods, expected outcomes, and any ethical considerations, along with required signatures and documentation.
What is the purpose of THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)?
The purpose of the study is to evaluate the role of exercise in enhancing tumor vascularity and improving the response to neoadjuvant therapy in patients with operable breast cancer, potentially leading to better treatment outcomes.
What information must be reported on THE EFFECTS OF EXERCISE TRAINING ON TUMOR VASCULARITY AND RESPONSE TO NEOADJUVANT THERAPY IN OPERABLE BREAST CANCER: A PHASE I-II STUDY (IDEA AWARD)?
The report must include participant demographics, exercise training protocols, tumor vascularity measurements, responses to neoadjuvant therapy, and any adverse effects observed during the study.
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