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Abuse of Marketed Analgesics and Its Contribution to the National Problem of Drug Abuse Len Palazzi, MD, MPH National Center for Injury Prevention and Control Centers for Disease Control and Prevention
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The first wave began with increased prescribing of opioids in the 1990s, with overdose deaths involving prescription opioids (natural and semi-synthetic opioids and methadone) increasing since at least 19993. The second wave began in 2010, with rapid increases in overdose deaths involving heroin4.
Opioids, sometimes called narcotics, are medications prescribed by doctors to treat persistent or severe pain.
Mechanisms of Drug Diversion Nurses, the largest group of healthcare professionals pilfering opioid analgesics from hospital supplies, represent a group of impaired health professionals who need assistance to cease these actions.
It started in the mid-1990s when the powerful agent OxyContin, promoted by Purdue Pharma and approved by the Food and Drug Administration (FDA), triggered the first wave of deaths linked to use of legal prescription opioids.
Results: In 2008, drug overdoses in the United States caused 36,450 deaths. OPR were involved in 14,800 deaths (73.8%) of the 20,044 prescription drug overdose deaths. Death rates varied fivefold by state. States with lower death rates had lower rates of nonmedical use of OPR and OPR sales.
In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to opioid pain relievers and healthcare providers began to prescribe them at greater rates.

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