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This document is a notice from the National Institutes of Health regarding the prospective grant of an exclusive patent license for the development of PANVAC, a colorectal cancer vaccine, to Bavarian
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How to fill out Notice of Prospective Grant of Exclusive License for PANVAC and Tumor Associated Antigens as Colorectal Cancer Vaccine

01
Read the instructions provided with the Notice of Prospective Grant of Exclusive License.
02
Fill out your contact information accurately in the designated sections.
03
Provide a clear description of the PANVAC and Tumor Associated Antigens being licensed.
04
Outline the intended use of the license and any potential commercial applications.
05
Specify the terms under which the exclusive license will be granted.
06
Include any relevant supporting documents or information.
07
Review the completed form for accuracy and completeness.
08
Submit the Notice to the appropriate licensing authority.

Who needs Notice of Prospective Grant of Exclusive License for PANVAC and Tumor Associated Antigens as Colorectal Cancer Vaccine?

01
Companies or organizations interested in developing or commercializing the PANVAC and Tumor Associated Antigens as a colorectal cancer vaccine.
02
Researchers seeking exclusive rights to work with the vaccine technology.
03
Medical institutions looking to implement the vaccine in clinical settings.
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People Also Ask about

The most common tumor marker for colorectal cancer is the carcinoembryonic antigen (CEA). Blood tests for this tumor marker can sometimes suggest someone might have colorectal cancer, but they can't be used alone to screen for or diagnose cancer.
A protein or other molecule that is found only on cancer cells and not on normal cells. Tumor-specific antigens can help the body make an immune response against cancer cells. They may be used as possible targets for targeted therapy or for immunotherapy to help boost the body's immune system to more cancer cells.
Guide to Tumor Markers Used in Cancer Tumor MarkerCancers Associated With Elevated Results"Normal" Results CA 19-9 Cancer Antigen 19-9 or Carbohydrate Antigen 19-9 Pancreas** and colorectal, liver, stomach and biliary tree cancers < 37 U/ml is normal > 120 U/ml is generally caused by tumor22 more rows
The most common tumor marker for colorectal cancer is the carcinoembryonic antigen (CEA). Blood tests for this tumor marker can sometimes suggest someone might have colorectal cancer, but they can't be used alone to screen for or diagnose cancer.
BioNTech and Moderna's personalized mRNA vaccines have shown promising anti-tumor effects in clinical trials. Currently, there are two personalized mRNA cancer vaccines, Moderna vaccine mRNA-4157 (encodes up to 34 neoantigens) and BioNTech vaccine BNT122 (encodes up to 20 neoantigens), in phase II clinical trials (45).
Methylated genes such as MLH1, VIM and SEPT9, could be used as biomarkers for colorectal cancer and as DNA-based colon cancer screening tests. Methylated Vimentin (mVim) is a validated stool-based biomarker for early detection of colorectal cancer available in the US (ColoGuard assay; LabCorp)[48].

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The Notice of Prospective Grant of Exclusive License for PANVAC and Tumor Associated Antigens as Colorectal Cancer Vaccine is an official notification indicating the intention to grant exclusive rights to a specific entity for the commercialization and further development of the PANVAC vaccine and associated tumor antigens targeted for colorectal cancer treatment.
Entities or organizations wishing to obtain exclusive rights to the PANVAC vaccine and Tumor Associated Antigens for colorectal cancer must file the Notice of Prospective Grant of Exclusive License. This typically includes potential licensees such as pharmaceutical companies, research institutions, or biotech firms.
To fill out the Notice of Prospective Grant of Exclusive License, applicants must provide detailed information about their organization, the scope of the intended use of the license, any prior research or development undertaken, and the beneficial impact expected from the commercialization of the vaccine.
The purpose of the Notice is to formally announce the intent to grant a license, allowing interested parties to express their interest in licensing the PANVAC vaccine and associated antigens, and to gauge the level of interest in the available technology.
The information that must be reported includes the proposing entity's contact details, a description of their qualifications, the proposed plan for development and commercialization, potential benefits to public health, and any previous research that supports their application.
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