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This document outlines the necessary forms and guidelines for submitting grant applications to the Public Health Service (PHS), specifically for the TSNRP awards, including detailed instructions for
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How to fill out PHS 398

01
Start with the cover page and fill in the application title, organization name, and other pertinent details.
02
Complete the project summary/abstract section, providing a concise overview of the proposed research.
03
Proceed to the introduction, which should outline the significance of your research and objectives.
04
Prepare the specific aims section, clearly stating the goals of the project.
05
Fill out the research strategy section, including significance, innovation, and approach.
06
Include biosketches for key personnel, following the required format and guidelines.
07
Prepare any necessary letters of support and append them to the application.
08
Complete the budget page, detailing project costs and justifications.
09
Review all sections for accuracy and completeness before submission.
10
Submit the application through the designated online portal and retain confirmation of submission.

Who needs PHS 398?

01
Researchers applying for NIH grant funding
02
Academic institutions seeking federal research support
03
Investigators conducting studies in biomedical fields
04
Organizations involved in health-related research initiatives
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A research plan is pivotal to a research project because it identifies and helps define your focus, method, and goals while also outlining the research project from start to finish. This type of plan is often necessary to: Apply for grants or internal company funding.
This Policy applies to all research funded or proposed for funding by the Public Health Service of the U.S. Department of Health and Human Services (“PHS”), including the National Institutes of Health (“NIH”).
The PHS 398 Research Training Program Plan Form is used only for Training applications and Multi-project applications with an "NRSA Training" Component. This form includes fields to upload several attachments including the Program Plan, Faculty Biosketches, and Data Tables.
The PHS 398 Research Plan form is used only for research, multi-project, and SBIR/STTR applications. This form includes fields to upload several attachments, including the Specific Aims and Research Strategy.
While SROs do not make decisions about funding, their summary statements are sent to program officers whose next stage of peer review leads to funding decisions made by other branches of the NIH. “I spend a lot of time going through their critiques,” Szymczyk said.
The PHS Policy, frequently referred to as the NIH Policy, requires each institution receiving PHS funds for research involving animals to submit detailed information regarding the institution's program for the care and use of animals (including farm animals, mice, and rats) to the Office of Laboratory Animal Welfare (

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PHS 398 is a standardized grant application form used by the Public Health Service (PHS) in the United States for applying for grants and cooperative agreements.
Any organization or individual applying for a grant or cooperative agreement from the Public Health Service is required to file PHS 398.
To fill out PHS 398, applicants must complete the required sections of the form, including project summary, budget, research strategy, and biographical sketches, following the guidelines provided in the application instructions.
The purpose of PHS 398 is to provide a uniform structure for grant applications, ensuring that all necessary information is presented in a consistent manner for review and funding decision-making.
PHS 398 requires reporting information such as project title, funding opportunity number, applicant organization details, project goals, research design and methodology, budget information, investigator credentials, and potential impact.
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