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This document outlines the administration protocol for Rituximab (Rituxan), including patient criteria, dosing, pre-infusion labs, vital signs guidelines, and outpatient discharge instructions tailored
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How to fill out RITUXIMAB (RITUXAN) – RAPID INFUSION

01
Verify the patient's identity and ensure informed consent is obtained.
02
Review the patient's medical history and determine if they are eligible for rapid infusion of Rituximab.
03
Prepare the Rituximab infusion according to the manufacturer's instructions.
04
Ensure that emergency resuscitation equipment is available in case of an allergic reaction.
05
Start the infusion using an intravenous (IV) line and monitor the patient closely for any adverse reactions during the process.
06
Administer the infusion at the recommended rapid infusion rate as specified in the guidelines.
07
Continuously monitor vital signs and laboratory parameters throughout the infusion.
08
Once the infusion is complete, observe the patient for any delayed reactions.

Who needs RITUXIMAB (RITUXAN) – RAPID INFUSION?

01
Patients with certain types of B-cell non-Hodgkin lymphoma.
02
Patients with chronic lymphocytic leukemia (CLL).
03
Patients with rheumatoid arthritis who have not responded to other treatments.
04
Patients with granulomatosis with polyangiitis (Wegener's granulomatosis) or microscopic polyangiitis.
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Nausea and vomiting. Eating small meals and snacks, avoiding fatty and fried food, drinking plenty of water can also help. Skin and hair changes: You may lose your body hair, including eyelashes and eyebrows. Skin rashes, dry skin and itching are also common.
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care provider. These medicines may hide a fever. This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine.
Starting with the second treatment cycle, your infusions will generally take between 3 and 4 hours. Previously untreated follicular lymphoma and DLBCL patients who do not have a serious infusion-related reaction during initial treatment may be able to receive follow-up infusions that last only 90 minutes.
This medicine may increase your risk of developing infections (eg, viral, bacterial, or fungal) during or after treatment with this medicine. Avoid being near people who are sick or have infections while you are using this medicine.
The 90-minute RITUXAN Infusion Rate for Appropriate Patients is1: 20% of the total dose over the first 30 minutes (75 mg/m2) 80% of the total dose over the following 60 minutes (300 mg/m2)
Administration1 INFUSIONINFUSION RATE First Initiate infusion at 50 mg/hr In the absence of infusion toxicity, increase the rate by 50 mg/hr every 30 minutes Maximum infusion rate is 400 mg/hr1 more row
First Infusion: Initiate infusion at a rate of 50 mg/hr. In the absence of infusion toxicity, increase infusion rate by 50 mg/hr increments every 30 minutes, to a maximum of 400 mg/hr.
Rituximab as an injection is given over 5 minutes. The first infusion will be given slowly because it can cause a reaction. Before treatment, you will be given medicines to help prevent or reduce any reaction. You may have the first infusion in hospital.

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Rituximab (RITUXAN) – Rapid Infusion is a monoclonal antibody used in the treatment of certain autoimmune diseases and types of cancer, including non-Hodgkin lymphoma and chronic lymphocytic leukemia. The rapid infusion method allows for faster administration of the drug, typically over a shorter duration than conventional infusion.
Healthcare providers or facilities that administer Rituximab (RITUXAN) via rapid infusion are typically required to file necessary documentation for treatment records and insurance reimbursement.
To fill out documentation for Rituximab (RITUXAN) – Rapid Infusion, providers should include patient identification, infusion details (dose and rate), premedication given, monitoring data during the infusion, and any adverse events noted.
The purpose of Rituximab (RITUXAN) – Rapid Infusion is to deliver therapy more quickly to patients, improving convenience and potentially enhancing patient comfort and satisfaction, while also maintaining the efficacy of the drug.
Information that must be reported includes the patient's name, treatment date, infusion rate, dose administered, any premedications used, vital signs before, during, and after the infusion, and any side effects experienced.
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