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This document details the requisition process for laboratory testing of KRAS and BRAF gene mutations, including specimen requirements, methodology, and associated clinical information necessary for
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How to fill out colon cancer mutation panel
How to fill out Colon Cancer Mutation Panel (KRAS & BRAF)
01
Obtain a sample of the patient's tumor tissue or blood.
02
Ensure the sample is properly labeled with patient information.
03
Send the sample to a laboratory certified for genetic testing.
04
Select the specific mutations to be tested (KRAS, BRAF).
05
Fill out the requisition form with accurate patient demographics and clinical information.
06
Indicate the reason for testing, including any prior treatments or therapies.
07
Submit the sample along with the requisition form to the laboratory for analysis.
Who needs Colon Cancer Mutation Panel (KRAS & BRAF)?
01
Patients diagnosed with advanced colorectal cancer.
02
Individuals with a family history of colorectal cancer.
03
Patients considering targeted therapies for their cancer treatment.
04
People exhibiting symptoms related to colorectal cancer and seeking diagnosis.
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What is KRAS and BRAF mutation in colon cancer?
BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined.
What does KRAS mutation mean in colon cancer?
Patients with BRAF mutations had worse OS compared with patients with wild-type BRAF with a median survival of 18.9 months versus 33.2 months (hazard ratio [HR] 1.52, 95% confidence interval [CI]: 1.25-1.86, P < . 001).
What is BRAF mutation in colon cancer?
An abnormal mutation in the KRAS gene happens early in the development of cancer. This abnormality is known as a driver mutation because it causes the switch to be locked in the “on” position and drives uncontrolled cell growth, leading a tumor to form.
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What is Colon Cancer Mutation Panel (KRAS & BRAF)?
The Colon Cancer Mutation Panel (KRAS & BRAF) is a diagnostic test that analyzes specific mutations in the KRAS and BRAF genes associated with colorectal cancer. These mutations can influence treatment decisions and patient prognosis.
Who is required to file Colon Cancer Mutation Panel (KRAS & BRAF)?
Healthcare providers, including oncologists and pathologists, are required to file the Colon Cancer Mutation Panel when diagnosing patients with colorectal cancer or assessing treatment options based on genetic markers.
How to fill out Colon Cancer Mutation Panel (KRAS & BRAF)?
To fill out the Colon Cancer Mutation Panel, a healthcare professional must provide patient details, including clinical history, request specific mutation testing, and ensure proper specimen handling and forwarding to the laboratory.
What is the purpose of Colon Cancer Mutation Panel (KRAS & BRAF)?
The purpose of the Colon Cancer Mutation Panel is to identify mutations in the KRAS and BRAF genes that may predict the effectiveness of certain therapies, guide treatment decisions, and provide information about the patient's cancer prognosis.
What information must be reported on Colon Cancer Mutation Panel (KRAS & BRAF)?
The report must include the patient's identification information, details of the specimen, test results indicating the presence or absence of KRAS and BRAF mutations, and any interpretations or recommendations based on those results.
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