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This document serves as a requisition form for the BCR-ABL Kinase Domain Mutations/ABL Sequencing test, which aids in assessing patients with chronic myeloid leukemia regarding therapy resistance
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How to fill out BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)
01
Obtain the BCR-ABL Kinase Domain Mutations/ABL Sequencing test kit and necessary materials.
02
Prepare the patient for blood sample collection, ensuring clear instructions regarding any pre-test requirements.
03
Collect the blood sample using appropriate techniques and safety measures.
04
Label the sample correctly with patient identification and test information.
05
Process the sample as per the test kit instructions, including any required centrifugation or storage conditions.
06
Send the processed sample to the laboratory for sequencing analysis.
07
Receive and review the laboratory results once the analysis is complete.
Who needs BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)?
01
Patients diagnosed with chronic myeloid leukemia (CML) who are undergoing treatment.
02
Individuals who exhibit resistance to standard therapy and may require alternative treatments.
03
Patients being evaluated for potential clinical trials related to CML.
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People Also Ask about
What does a positive BCR-ABL test mean?
AML with BCR-ABL1 is generally reported to have a poor prognosis with conventional chemotherapy and TKI treatment, but TKI treatment may be effective in elderly patients who have low tumor burden and without chromosomal abnormalities and ABL kinase domain mutations conferring resistance to TKI treatment.
What does the BCR-ABL mutation do?
BCR::ABL mutations can be a major cause of imatinib resistance once patient starts showing resistance to this drug. BCR::ABL kinase domain mutations detected after Imatinib failure have varied from 19 % to 90 %, depending on the methodology applied [9].
What type of cancer is BCR-ABL?
BCR-ABL1 genetic testing is most often used with other tests to diagnose or rule out two specific types of blood cancer: Chronic myeloid leukemia (CML). Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). This is a type of acute lymphoblastic leukemia that has the Philadelphia chromosome.
What does the BCR-ABL gene do?
Bcr-Abl induces mitogenesis in fibroblast and hematopoietic cell transformation models (reviewed in reference 31) and protects cells from apoptosis induced by numerous stimuli including cytokine withdrawal, DNA damage, and Fas activation (2, 3, 12, 24–26).
What is the BCR-ABL mutation?
An abnormal BCR-ABL1 gene is an acquired genetic change. That means you don't inherit it from your parents, and you can't pass it on to your children. Acquired changes happen after birth if cells make a mistake when dividing to make new cells or if your DNA is damaged from exposure to substances that cause cancer.
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What is BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)?
BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative) is a testing method used to detect specific mutations in the BCR-ABL gene that are associated with resistance to certain tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML). This type of sequencing determines the presence of mutations in the kinase domain of the ABL gene.
Who is required to file BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)?
Healthcare providers, particularly oncologists and hematologists, who are treating patients with chronic myeloid leukemia (CML) or acute lymphoblastic leukemia (ALL) and need to assess resistance to treatment may be required to file BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative) tests.
How to fill out BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)?
To fill out the BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative) form, you need to provide patient information including demographic details, medical history related to CML treatment, and details of previous therapies. Additionally, you should indicate the specific mutations being tested and any clinical context relevant to the test.
What is the purpose of BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)?
The purpose of BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative) is to identify mutations that may confer resistance to therapy in patients with CML, guiding clinicians in treatment decisions and helping to predict patient response to tyrosine kinase inhibitors.
What information must be reported on BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative)?
The reported information on BCR-ABL Kinase Domain Mutations/ABL Sequencing (Qualitative) must include the specific mutations identified, their clinical significance in relation to treatment response, and recommendations for ongoing management based on the mutation profile.
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