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This document is used to request significant changes to an already approved animal care and use protocol, requiring review and approval from the Institutional Animal Care and Use Committee (IACUC).
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How to fill out amendment to iacuc animal

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How to fill out Amendment to IACUC Animal Protocol

01
Obtain the current IACUC Animal Protocol form.
02
Review the existing protocol to determine what changes are necessary.
03
Fill out the amendment section, specifying the changes you are proposing.
04
Provide a clear justification for each change in the designated area.
05
Ensure all researchers involved in the protocol sign off on the amendment.
06
Submit the completed amendment to the IACUC office.
07
Await approval from the IACUC before implementing any changes.

Who needs Amendment to IACUC Animal Protocol?

01
Researchers conducting animal studies who need to modify their existing approved protocols.
02
Any individual or institution whose animal research plans require updates due to new findings or changes in the study design.
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Protocols are allowed unlimited amendments (minor or significant) per protocol as long as the change is within the scope of the original abstract. Amendments that only address personnel changes do not affect this count. However, a change in PI DOES affect the count and is considered a significant amendment.
The IACUC has defined a Significant Change as any deviation from the protocol that substantially alters or affects the overall study objectives/rationale, specific approved procedures, or the potential for pain, distress and discomfort in the animals.
The IACUC cannot permit any activities on live vertebrate animals without an approved IACUC protocol. This is required by the Public Health Service Policy on the Humane Care and Use of Laboratory Animals (PHS Policy) and the USDA Animal Welfare Regulations.
Animal subject The IACUC will not require an animal use protocol for activities involving lower level invertebrate species (e.g., brine shrimp, fruit flies, etc.).
Observational studies involving animals residing in zoos or animal rescues are exempt from IACUC oversight. Passive collection of samples is allowed provided it does not impact animal behavior or nutrition and is noninvasive.
All vertebrate animals (animals with a backbone) require an IACUC protocol. Higher invertebrates also require an IACUC protocol and include: octopus, squid, nautilus, lobsters, crabs and hermit crabs, and crayfish.
Which of the following statements is true about modifications or amendments to animal protocols after IACUC approval? Significant changes must be reviewed and approved by the IACUC before they are implemented.

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An Amendment to IACUC Animal Protocol is a formal change or modification to an existing animal research protocol that has already been approved by the Institutional Animal Care and Use Committee (IACUC).
Researchers or principal investigators who wish to make changes to their previously approved animal protocol are required to file an Amendment to IACUC Animal Protocol.
To fill out an Amendment to IACUC Animal Protocol, researchers typically need to provide detailed information about the proposed changes, the reasons for those changes, and any potential impacts on animal welfare and study outcomes.
The purpose of an Amendment to IACUC Animal Protocol is to ensure that any changes to the original protocol are reviewed for compliance with ethical standards and regulatory requirements, ensuring the continued protection of animal welfare in research.
The information that must be reported on an Amendment to IACUC Animal Protocol typically includes a description of the changes, justifications for the modifications, the potential impact on the animals involved, and any changes to the research methodologies.
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