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This document is used to report discrepancies in HLA typing results between donor centers and transplant centers within the Marrow Donor Program Belgium.
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How to fill out Discrepant Typing Report

01
Begin by entering the report title at the top of the document.
02
Fill in the date of the report.
03
Provide the patient's identification details, including name, date of birth, and medical record number.
04
Indicate the sample type (blood, tissue, etc.) and the date the sample was collected.
05
Document the reason for the discrepancy found in the typing results.
06
List the test methods used for typing and any discrepancies observed.
07
Include any confirmatory tests that were performed following the initial discrepancy.
08
Detail the conclusions drawn from the investigation of the discrepancy.
09
Sign and date the report, ensuring that all required personnel have approved the document.

Who needs Discrepant Typing Report?

01
Healthcare professionals involved in transfusion medicine.
02
Blood banks and clinical laboratories.
03
Patients undergoing blood transfusions or organ transplants.
04
Regulatory agencies overseeing blood safety and transfusion practices.
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People Also Ask about

ABO discrepancies occur any time the interpretations of a person's red cell and serum grouping do not agree. ABO discrepancy takes on many forms, and acquired B is a great, if not terribly common, example.
Acquired B phenomenon — a temporary condition caused by bacterial enzymes that modify the A antigen on the cell surface, making them temporarily look like B antigens.
(7) Which typing results are most likely to occur when a patient has an acquired B antigen? In forward typing, a 1+ reaction with anti-B is suspicious because of the weak reaction and the normal reverse grouping that appears to be group A. This may be indicative of an acquired antigen.
This ABO discrepancy can be resolved by testing patient plasma with patient red blood cells. Patients who are truly group A, without any true B antigen, will demonstrate a negative auto control.
Repeating the test with washed cells typically resolves the discrepancy. In cases of reverse typing discrepancies, clinicians may utilize a saline replacement technique.
Group II - Discrepancies that are associated with unexpected or atypical reactions in the forward grouping, specifically mixed field reactions.
Usually, acquired B occurs when the RBCs from a blood group A patient come in contact with bacterial enzymes known as “deacetylases” carried by bacteria that live in the colon (typically gram-negative rods).
False positive or false negative results can occur due to contamination of test materials, improper reaction temperature, improper storage of materials, omission of test reagents and certain disease states. Suppressed or weak expression of blood group antigens may give rise to false negative reactions.

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A Discrepant Typing Report is a document used to notify relevant authorities or departments about discrepancies observed in typing or data entry processes, ensuring data integrity and accuracy.
Individuals or organizations involved in data entry, processing, or management who identify discrepancies are typically required to file a Discrepant Typing Report.
To fill out a Discrepant Typing Report, provide all necessary information including the details of the discrepancies observed, relevant identifiers, and any corrective actions taken or recommended.
The purpose of a Discrepant Typing Report is to formally document and address discrepancies in data to maintain accuracy, uphold standards, and prevent data-related issues.
The report must include details such as the nature of the discrepancy, the affected data fields, the context of the error, identification numbers, and actions taken to resolve the issue.
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