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The reaction requires different host enzymes and is resistant to rifampicin and streptolydigin inhibitors of RNA polymerase. However RNA synthesis is essential for OX174 DNA synthesis the reaction is inhibited by low concentrations of actinomycin D all four ribonucleoside triphosphates are required and an average of one phosphodiester bond links DNA to RNA in the isolated doublestranded circles. Thus we presume that as in the case of M13 synthesi...
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