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This document outlines the procedures and agreements for transferring research materials from the University of Pennsylvania to recipient institutions for non-commercial research purposes.
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People Also Ask about
Is AAV a rare disease?
Epidemiology of AAV ANCA-associated vasculitides are rare conditions, affecting between 10 and 20 individuals per million people. GPA is the most common of the 3 main forms, affecting between 5 and 10 individuals per million people.
What is the AAV virus in English?
Adeno-associated virus. Adeno-associated viruses (AAV) are single stranded DNA viruses that have not been found to cause pathology in humans. The AAV is dependent on helper viruses for replication and for productive infection. AAV contains two genes, rep and cap, that are required for its replication.
What is AAV in English?
Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae.
What is AAV called in English?
Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae.
Is AAV harmful?
More than 120 clinical trials using AAV have shown vector safety, with a transient and asymptomatic hepatitis as the most severe side effect. In comparison to the widespread use of AAV vectors in clinical, preclinical, and basic research, there has been limited study of the interaction of the parental virus in humans.
What is the AAV format?
Simply put, AAV is a protein shell surrounding and protecting a small, single-stranded DNA genome of approximately 4.8 kilobases (kb). AAV belongs to the parvovirus family and is dependent on co-infection with other viruses, mainly adenoviruses, in order to replicate.
What does the AAV virus do?
Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to target cells, and has attracted a significant amount of attention in the field, especially in clinical-stage experimental therapeutic strategies.
What is adeno-associated virus serotype 2 AAV2?
Adeno-associated virus serotype 2 (AAV-2) is a replication-deficient parvovirus that infects humans, but produces no significant pathology (Blacklow et al., 1968a). The virus consists of a 5 kb single-stranded DNA genome, contained within a non-enveloped icosahedral capsid (Xie et al., 2002).
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What is A-OT AAV2/1?
A-OT AAV2/1 is a specific form used for reporting certain activities, requirements, or information related to a regulatory or compliance framework.
Who is required to file A-OT AAV2/1?
Entities or individuals that meet specific criteria set by the relevant regulatory authority are required to file A-OT AAV2/1.
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The purpose of A-OT AAV2/1 is to collect necessary data for compliance, reporting, or regulatory oversight purposes.
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Information required on A-OT AAV2/1 typically includes details such as the reporting entity, relevant dates, and specific activities or transactions that need to be disclosed.
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