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This document provides guidelines for the humane and effective euthanasia of mice and rats, detailing methods, procedures, and documentation requirements in accordance with AVMA guidelines.
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How to fill out Institutional Animal Care and Use Program Guidelines

01
Start by downloading the Institutional Animal Care and Use Program Guidelines from the official website.
02
Review the guidelines carefully to understand the requirements and expectations.
03
Gather necessary information about the animal use protocol, including types of animals, research purpose, and procedures involved.
04
Complete the application form, ensuring all sections are filled out accurately.
05
Include detailed descriptions of housing, care, and procedures involving the animals.
06
Obtain necessary approvals or endorsements from relevant departments or committees.
07
Submit the filled-out guidelines to the designated Institutional Animal Care and Use Committee (IACUC).
08
Respond to any feedback or requests for additional information from the IACUC.

Who needs Institutional Animal Care and Use Program Guidelines?

01
Researchers conducting studies involving animals.
02
Institutional administrators overseeing animal care policies.
03
Animal care staff responsible for the welfare of the animals.
04
Regulatory bodies ensuring compliance with animal welfare standards.
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Links to these important documents follow. Animal Welfare Act and Regulations. USDA/APHIS Animal Welfare Publications and Policy. Office of Laboratory Animal Welfare (NIH) Office of Animal Care and Use (NIH) PHS Policy on Humane Care and Use of Laboratory Animals.
Each animal protocol must include: (1) a justification for using animals, the number of animals to be used, and the species chosen, (2) the procedures or drugs to be used to eliminate or minimize pain and discomfort, (3) a description of the methods and sources used to search for alternatives to painful procedures, and
An Animal Use Protocol (AUP) is a formal application to use live animals in research, teaching or at public events. The AUP provides details about the project, category of invasiveness, explains justification of the use of animals, lists the staff involved, and details the procedures to be performed on the animals.
The European Convention for the Protection of Animals kept for Farming Purposes (ETS No. 087) is a "framework Convention" which gives principles for the keeping, care and housing of animals, in particular in intensive breeding systems.
An Animal Utilization Protocol (AUP) is the formal application to use live animals in research, teaching or at public events.
An animal use protocol must be submitted to the IACUC for approval of any research, testing, and/or teaching involving animals. To submit an AUP for IACUC review, log in to the iRIS system.
An institutional animal care and use committee (IACUC) is required by federal regulations for most institutions that use animals in research, teaching, and testing. The IACUC has a key oversight role, including the review and approval of animal use activities, and inspection of animal facilities.
Each animal use protocol (AUP) must be reviewed by full IACUC committee at least once every three years, and can be reviewed more frequently if the committee wishes. The protocol must cover at least these points: a. Identification of the species and approximate number of animals to be used.

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The Institutional Animal Care and Use Program Guidelines are regulations and policies designed to ensure the humane and ethical treatment of animals used in research, teaching, and testing.
Researchers, institutions, and organizations that use animals for research or educational purposes are required to file Institutional Animal Care and Use Program Guidelines.
To fill out the guidelines, applicants must provide detailed information regarding the proposed use of animals, including the purpose of the study, animal care practices, and measures to minimize pain and distress.
The purpose of the guidelines is to ensure compliance with ethical standards, protect animal welfare, and promote responsible use of animals in research and educational activities.
The information that must be reported includes the type of animals used, the projected number of animals, research objectives, methods of care and housing, and any procedures that may cause pain or distress to the animals.
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