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2011 International Conference on Food Engineering and Biotechnology IPCBEE vol.9 2011 2011 IACSIT Press Singapoore Mechanism of RNA interference RNAi Current concept Soumyaparna Das Avinash Marwal D.
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How to fill out mechanism of RNA interference?

01
Understand the basics of RNA interference: Familiarize yourself with the concept of RNA interference, which is a process by which small RNA molecules inhibit gene expression or translation.
02
Identify the key components of the mechanism: Determine the essential elements involved in RNA interference, such as small interfering RNAs (siRNAs), microRNAs (miRNAs), and the RNA-induced silencing complex (RISC).
03
Study the initiation step: Explore how RNA interference begins with the introduction of double-stranded RNA (dsRNA) into the cell, either through exogenous delivery or endogenous production.
04
Examine the processing step: Investigate the processing of dsRNA into siRNAs or miRNAs, which involves enzymes like Dicer and Drosha that cleave dsRNA into small RNA fragments.
05
Explore the assembly of RISC: Learn about the assembly of RISC, where one strand of the processed siRNA or miRNA is loaded onto an Argonaute protein within the RISC complex.
06
Understand the target recognition and degradation steps: Delve into how the guide strand of the siRNA or miRNA within RISC recognizes and binds to its target mRNA, leading to the degradation of the mRNA molecule.
07
Study the post-transcriptional gene silencing process: Gain knowledge about how RNA interference can regulate gene expression post-transcriptionally, preventing the translation of target mRNAs into proteins.

Who needs mechanism of RNA interference?

01
Researchers in molecular biology: Scientists studying gene regulation, gene expression, and genetic manipulation often require an understanding of RNA interference to investigate its role in various biological processes.
02
Biomedical scientists: Professionals working in biomedical research may need to comprehend the mechanism of RNA interference to develop potential therapies or treatments based on modulating gene expression through siRNAs or miRNAs.
03
Pharmaceutical industry: Companies involved in drug discovery and development can benefit from understanding the mechanism of RNA interference when designing RNA-based therapeutics for various diseases, including cancer, viral infections, and genetic disorders.
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RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules. It is a powerful mechanism used by cells to regulate gene expression and plays a vital role in various biological processes.
The mechanism of RNA interference is a biological process that occurs within cells and does not require any filing or submission.
As RNA interference is a biological process, it does not require any specific form or method of filling out.
The purpose of the mechanism of RNA interference is to regulate gene expression and control the activity of specific genes within cells.
As RNA interference is a cellular process, there is no specific information that needs to be reported.
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Related Links

RNA Interference: Biology, Mechanism, and Applications - NCBI
Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of ... analysis revealed a two-step mechanism of RNAi-induced gene silencing. ..... At present, little is known about the RNAi intermediates, RNA- protein ...
RNA interference - Wikipedia, the free encyclopedia
RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene ..... Part of the mechanism for how these RNA upregulate genes is known: dicer and ... Related functions such as histone modification may have already been present in the ..... "RNA interference: concept to reality in crop improvement" .
Therapeutic Applications of RNA Interference
During recent decades there have been remarkableadvances in biology, in which one of the most important discoveries is ribonucleic acid interference ( RNAi)

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Relevant keywords

Maine RNA siRNA RISC r2d2 dcr-2 RNAi PPD elegans miRNA mRNA RNase dsRNA polymerase par-1 Dcr-1 PIWI holo antisense PAZ Loqs ATP 2004 Hannon transcriptional m-RNA Macino RdRP DNA Effector Biol

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