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This document outlines the physician orders and protocols related to Warfarin therapy, including medication orders, dosages based on INR levels, risk factors, drug interactions, and monitoring requirements.
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How to fill out WARFARIN PROTOCOL

01
Gather necessary patient information including medical history and current medications.
02
Check INR levels to determine the appropriate warfarin dose.
03
Educate the patient about warfarin, including its purpose and potential side effects.
04
Provide clear instructions on how to take warfarin, including timing and dietary considerations.
05
Set up a regular monitoring schedule for INR testing to ensure dosage remains effective and safe.
06
Document all information and patient interactions accurately.

Who needs WARFARIN PROTOCOL?

01
Patients with atrial fibrillation.
02
Individuals with artificial heart valves.
03
Patients with a history of deep vein thrombosis or pulmonary embolism.
04
Individuals at risk for blood clots due to certain medical conditions.
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Second, warfarin is metabolized in the liver by the P450 cytochrome CYP2C9. It has a half-life of degradation of approximately 35 hours, which means that when a fixed dose is administered orally, it takes approximately 7 to 9 days before the warfarin level or INR reaches a steady state.
Therefore, heparin is often used as a “bridge” when initiating warfarin therapy in patients with AF, not only because physicians feel a need to begin anticoagulation as soon as possible for stroke prevention but also because they want to protect patients from this presumed transient hypercoagulable state.
Because of the latter action, warfarin has the potential of exerting a transient procoagulant effect early in therapy. To counter that, heparin 'bridging' is recommended for a minimum of 5 days and until the INR is 2.0 or above for at least 24 h [7].
Treatment / Management Discontinue warfarin 5 days before surgery. Three days before surgery, start subcutaneous LMWH or unfractionated heparin (UFH) at therapeutic doses, depending on the patient's renal function.
For surgery or procedures with a high bleeding risk, your warfarin will need to stop 5 days before the planned date. This allows your INR to return to a normal level and reduces the risk of bleeding.
The typical induction dose of warfarin is 10 mg daily for 2 days, but this should be tailored to individual requirements. A low starting dose (5 mg) is often more suitable for frail or elderly people, people with a low body weight, people with liver disease or cardiac failure, and people at high risk of bleeding.
The usual warfarin dose for adults is 10mg a day for the first 2 days, then between 3mg and 9mg a day after that. The usual warfarin dose for children depends on how much they weigh. Warfarin tablets come in 4 different strengths.
The BRIDGE Trial Warfarin treatment is typically stopped 5 days before an elective procedure to allow its anticoagulant effect to wane; it is resumed after the procedure, when hemostasis is secured, at which point 5 to 10 days of treatment is required to attain therapeutic anticoagulation.

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Warfarin Protocol is a set of guidelines and procedures for the management and monitoring of patients on the anticoagulant medication warfarin. It includes information on dosing, monitoring of INR levels, and guidelines for patient education.
Healthcare providers, including physicians and pharmacists, who manage patients on warfarin are required to file the Warfarin Protocol to ensure compliance with safety and monitoring standards.
To fill out the Warfarin Protocol, healthcare providers must complete sections including patient identification, current medication dosages, INR results, any contraindications, and necessary adjustments to the warfarin dosage as per guidelines.
The purpose of the Warfarin Protocol is to standardize the management of patients taking warfarin to minimize the risk of adverse events, ensure effective anticoagulation, and improve patient safety.
Information that must be reported on the Warfarin Protocol includes patient demographic details, warfarin dosing information, INR monitoring results, dietary considerations, any drug interactions, and patient adherence to the regimen.
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