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Patients should be observed for 6 hours after the initial dose to monitor for signs and symptoms of bradycardia. Special Populations Hepatic Impairment In subjects with mild moderate or severe hepatic impairment no change in Cmax was observed but AUC was increased respectively by 12 44 and 103. Renal Impairment In patients with severe renal impairment Cmax and AUC are increased by 32 and 43 respectively and -phosphate Cmax and AUC are increased by 25 and 14 respectively with no change in...
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