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These instructions contain information for preparing grant applications to the National Institutes of Health (NIH) and other Public Health Service agencies.
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How to fill out PHS 398

01
Download the PHS 398 application form from the official NIH website.
02
Review the instructions thoroughly to understand the requirements.
03
Fill out the cover page with the project title, applicant details, and institution.
04
Complete the project summary and relevance sections.
05
Detail the research strategy, including specific aims, significance, innovation, and approach.
06
Include information on human subjects or animal research if applicable.
07
List key personnel and their roles in the project.
08
Provide a budget justification if required.
09
Review all sections for completeness and accuracy.
10
Submit the completed form electronically through the NIH eRA Commons.

Who needs PHS 398?

01
Researchers applying for NIH grants.
02
Institutions seeking funding for health-related projects.
03
Organizations conducting research involving human subjects or animals.
04
Principal Investigators (PIs) submitting project proposals to the NIH.
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People Also Ask about

A research plan is pivotal to a research project because it identifies and helps define your focus, method, and goals while also outlining the research project from start to finish. This type of plan is often necessary to: Apply for grants or internal company funding.
This Policy applies to all research funded or proposed for funding by the Public Health Service of the U.S. Department of Health and Human Services (“PHS”), including the National Institutes of Health (“NIH”).
The PHS 398 Research Training Program Plan Form is used only for Training applications and Multi-project applications with an "NRSA Training" Component. This form includes fields to upload several attachments including the Program Plan, Faculty Biosketches, and Data Tables.
The PHS 398 Research Plan form is used only for research, multi-project, and SBIR/STTR applications. This form includes fields to upload several attachments, including the Specific Aims and Research Strategy.
While SROs do not make decisions about funding, their summary statements are sent to program officers whose next stage of peer review leads to funding decisions made by other branches of the NIH. “I spend a lot of time going through their critiques,” Szymczyk said.
The PHS Policy, frequently referred to as the NIH Policy, requires each institution receiving PHS funds for research involving animals to submit detailed information regarding the institution's program for the care and use of animals (including farm animals, mice, and rats) to the Office of Laboratory Animal Welfare (

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PHS 398 is an application form used for applying for extramural research grants from the Public Health Service (PHS), which includes the National Institutes of Health (NIH).
Individuals and organizations applying for PHS funding, such as researchers at universities, academic institutions, and non-profit organizations, are required to file PHS 398.
To fill out PHS 398, applicants must follow the detailed instructions provided in the PHS 398 application guide, which includes sections for project summary, budgeting, and biographical sketches.
The purpose of PHS 398 is to provide a standardized format for researchers to present their proposed projects and secure funding for their research initiatives.
The PHS 398 requires the reporting of information such as the project title, objectives, research strategy, budget, biographical sketches of the principal investigators, and other relevant details about the study.
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