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This document serves as an application for the inclusion of human pluripotent stem cells in the NIH Human Pluripotent Stem Cell Registry, detailing required applicant and cell line information and
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How to fill out Application for Inclusion of Human Pluripotent Stem Cells on the NIH Human Pluripotent Stem Cell Registry

01
Gather the necessary information about the human pluripotent stem cells, including their source and characterization.
02
Complete the application form, making sure to include all required sections.
03
Provide detailed descriptions of the research and potential applications involving the stem cells.
04
Include any relevant documentation, such as ethical approvals and consent forms.
05
Review the application for accuracy and completeness before submission.
06
Submit the application through the NIH eRA Commons system or the appropriate submission portal.
07
Monitor the status of your application after submission and be prepared to respond to any requests for additional information.

Who needs Application for Inclusion of Human Pluripotent Stem Cells on the NIH Human Pluripotent Stem Cell Registry?

01
Researchers and institutions planning to use human pluripotent stem cells in their studies.
02
Companies looking to develop therapies utilizing human pluripotent stem cells.
03
Regulatory agencies and ethical review boards that require compliance with NIH guidelines.
04
Any entity that aims to access or utilize stem cells recognized by the NIH for funded research.
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People Also Ask about

The greatest therapeutic promise of human ESC (hESC) is to generate specialized cells to replace damaged tissue in patients suffering from various degenerative diseases. However, the signaling mechanisms involved in lineage restriction of ESC to adopt various cellular phenotypes are still under investigation.
One of the most promising applications of stem cell research is in regenerative medicine, where stem cells can replace damaged or lost cells in the body. This process can potentially treat various diseases and conditions, including Parkinson's, multiple sclerosis, stroke, and spinal cord injuries.
Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous disease. HCC cell lines established from different patients would be useful in elucidating the molecular pathogenesis. However, success of HCC primary culture establishment remains at low rate.
Human embryonic stem cell (hESC), as defined by the NIH: "A type of pluripotent stem cell derived from early stage human embryos, up to and including the blastocyst stage.
hPSCreg is a global registry for human pluripotent stem cell lines (hPSC-lines). It aims to provide to the community. a central and searchable hub for available hPSC-lines. a central registry of clinical studies based on hPSC-lines. a standardized identifier for hPSC-lines and register of these standard names.
Research with human embryonic stem cell (hESC) lines has attracted increasing attention over the last decade because these cells have the capability to proliferate indefinitely and to differentiate into any cell type of the body.
There are many applications of iPSCs in the fields of gene therapy, disease modeling and drug discovery. Somatic cells from the patient are used for the generation of diseased iPSCs.
The four CT Human embryonic stem cell (hESC) lines are CT-1, CT-2, CT-3, and CT-4. They are NIH Human ESC Registry-approved. CT-2 is the most widely used of the four lines.

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The Application for Inclusion of Human Pluripotent Stem Cells on the NIH Human Pluripotent Stem Cell Registry is a formal request that allows researchers to include their human pluripotent stem cell lines in a centralized database maintained by the NIH, facilitating access for researchers worldwide.
Any researcher or institution that develops or holds human pluripotent stem cell lines intended for research purposes must file an Application for Inclusion with the NIH.
To fill out the application, researchers must complete and submit a standardized form provided by the NIH, detailing information such as the source of the cell line, culture conditions, and consent documents.
The purpose of the application is to promote transparency and accessibility of human pluripotent stem cell lines for research, ensuring that all included lines meet ethical and scientific standards.
The application must report information including the cell line's origin, derivation method, characterization data, relevant ethical approvals, and other details essential for transparency and reproducibility in research.
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