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This document is a comprehensive form used to collect demographic, clinical, and epidemiological information related to patients suspected of having Hemolytic Uremic Syndrome (HUS).
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How to fill out HEMOLYTIC UREMIC SYNDROME (HUS) INVESTIGATION FORM

01
Gather all necessary patient information including name, age, and medical history.
02
Indicate the reason for investigation, including any symptoms such as diarrhea, vomiting, or gastrointestinal issues.
03
Collect laboratory test results, including complete blood count (CBC), renal function tests, and stool cultures.
04
Document any recent exposure to high-risk foods or water sources that may have caused the condition.
05
Note any previous illnesses or conditions that could be relevant to the diagnosis of HUS.
06
Ensure that all sections of the form are filled out accurately and completely.
07
Review the form for any missing information before submission.

Who needs HEMOLYTIC UREMIC SYNDROME (HUS) INVESTIGATION FORM?

01
Patients presenting with symptoms indicative of Hemolytic Uremic Syndrome.
02
Individuals with a history of recent gastrointestinal infections, especially those caused by E. coli.
03
Healthcare professionals needing to report cases for public health tracking.
04
Patients with acute kidney injury where HUS is a differential diagnosis.
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Patients with TTP have the same three features seen in children with HUS but also have fever and neurological findings. The diagnosis is made by assaying ADAMTS13 activity. This test requires care to standardize the assay procedure to ensure the accuracy and validity of the results.
Hemolytic uremic syndrome (HUS) is a condition that affects the blood and blood vessels. It results in: the destruction of blood platelets (cells involved in clotting) a low red blood cell count (anemia)
Diagnosis of HUS If the disorder is suspected, urinalysis, peripheral blood smear, reticulocyte count, serum lactic dehydrogenase (LDH), haptoglobin, renal function tests, serum bilirubin (direct and indirect), PT, PTT, fibrinogen, and direct antiglobulin test are done. ADAMTS13 enzyme activity levels may be helpful.
ADAMTS13 assay: A lack of activity in the ADAMTS13 protein causes TTP. For this test, a sample of blood is drawn from a vein, usually in your arm. The blood is sent to a special lab to test for the protein's activity. Genomic testing may be done for the ADAMTS13 gene to diagnose inherited TTP.
Tests look for the presence of different things that indicate hemolytic uremic syndrome: Pee tests look for blood or protein. Blood tests detail your red blood cell levels and platelet levels. Stool tests check for the presence of E. A kidney biopsy shows damage to your kidney and sometimes the cause of the damage.
Diagnosis of HUS ADAMTS13 activity is low in TTP but is usually not decreased in HUS. This enzyme is a plasma protease that cleaves von Willebrand factor; deficiency causes thrombotic thrombocytopenic purpura (TTP), and decreased ADAMTS13 activity levels may differentiate atypical cases of TTP from HUS.
The clinical presentation of TMA varies widely. The conventional distinction between TTP and HUS, based on predominant neurologic involvement and more severe thrombocytopenia in TTP, and more severe acute kidney injury (AKI) in HUS, is seldom clear-cut, and the clinical presentations can overlap.
Lab tests might include: Blood tests. These tests can show if the red blood cells are damaged. Blood tests also can show a low platelet count, low red blood cell count or a higher than usual level of a waste product usually removed by the kidneys, called creatinine.

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The HEMOLYTIC UREMIC SYNDROME (HUS) INVESTIGATION FORM is a standardized document used to collect clinical, laboratory, and epidemiological data related to suspected cases of HUS, which is a serious condition characterized by hemolytic anemia, acute renal failure, and thrombocytopenia.
Healthcare professionals, including physicians and public health officials, are required to file the HUS INVESTIGATION FORM whenever they suspect cases of HUS in patients to ensure appropriate tracking and management of the condition.
To fill out the HUS INVESTIGATION FORM, providers must gather and enter patient information including demographics, clinical symptoms, laboratory results, and potential exposure history, making sure to follow the specified guidelines outlined by health authorities.
The purpose of the HUS INVESTIGATION FORM is to facilitate the identification and monitoring of HUS cases, guide public health interventions, and enhance awareness and understanding of the syndrome's epidemiology.
The information that must be reported includes patient demographics, clinical presentation, laboratory test results, medical history, and any known exposures that could be related to the onset of HUS.
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