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Chemistry 2283g Experiment 5 Electrophilic Aromatic Substitution EXPERIMENT 5: Electrophilic Aromatic Substitution A FriedelCrafts Ablation Reaction TH Relevant Sections in the text (Wade, 7 ed.)
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01
Understand the reaction mechanism: Before proceeding with the reaction, it is essential to have a clear understanding of the electrophilic substitution reaction mechanism. Learn about the different steps involved and any necessary reagents or catalysts.
02
Identify the reactants and products: Determine the specific reactants that are needed for the electrophilic substitution reaction. These reactants typically include an aromatic compound and an electrophilic reagent. Identify the desired product(s) that will be formed as a result of the reaction.
03
Prepare the reaction conditions: Set up the appropriate reaction conditions, such as selecting a suitable solvent and ensuring the reaction takes place under the right temperature and pressure. The reaction conditions can vary depending on the specific electrophilic substitution reaction being performed.
04
Handle the reactants safely: Electrophilic substitution reactions often involve reactive or toxic compounds. It is crucial to follow proper safety precautions while handling these substances. Use appropriate personal protective equipment and work in a well-ventilated area.
05
Carry out the reaction: Add the reactants in the correct stoichiometric ratios to a suitable reaction vessel under the prescribed reaction conditions. Stir or heat the reaction mixture as required, ensuring that all reactants are well-mixed.
06
Monitor the progress of the reaction: Depending on the reaction, it may take minutes to hours for the reaction to reach completion. Monitor the progress by using analytical techniques like TLC (thin-layer chromatography) or by measuring the reaction's physical changes.
07
Purify the product: After the reaction, purify the desired product using appropriate purification techniques like recrystallization, distillation, or column chromatography. This step helps remove impurities and isolate the product in its pure form.

Who needs electrophilic substitution reaction:

01
Organic chemists: Electrophilic substitution reactions are commonly used in organic chemistry for the synthesis of various compounds. Organic chemists, including researchers, students, and professionals, often utilize these reactions to create new molecules or modify existing ones.
02
Pharmaceutical industry: The pharmaceutical industry heavily relies on electrophilic substitution reactions to design and synthesize new drug molecules. These reactions help chemists introduce specific functional groups into aromatic compounds, thereby enhancing the desired biological activity of the target drug.
03
Material scientists: Electrophilic substitution reactions have applications beyond organic synthesis. Material scientists may utilize these reactions to functionalize aromatic compounds for various purposes, such as developing new materials with specific electronic or optical properties.
In summary, understanding the mechanism, identifying reactants and products, preparing suitable reaction conditions, handling reactants safely, carrying out the reaction, monitoring the progress, and purifying the product are essential steps in filling out an electrophilic substitution reaction. This reaction is commonly used by organic chemists, the pharmaceutical industry, and material scientists for various applications.
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Electrophilic substitution reaction involves the replacement of an atom or a group of atoms in a molecule by an electrophile.
Researchers, chemists, and scientists working in the field of organic chemistry are required to conduct and report electrophilic substitution reactions.
To fill out an electrophilic substitution reaction report, one must provide details such as reactants, reagents, reaction conditions, and the anticipated products.
The purpose of electrophilic substitution reaction is to introduce specific functional groups or modify existing functional groups in organic molecules.
Information such as reactants, reagents, reaction conditions, yields, and any observed side reactions must be reported on an electrophilic substitution reaction.
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