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This document serves as a newsletter for the North Texas Section American Industrial Hygiene Association, detailing upcoming events, meetings, and updates related to occupational health and safety.
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Autoimmune hemolytic anemia (AIHA) is a decompensated acquired hemolysis caused by the host's immune system acting against its own red cell antigens.
Approximately 5-10% of all AIHAs are DAT negative. The polybrene test can detect DAT-negative AIHA. In addition, the immunoradiometric assay (IRMA) for red blood cell–bound IgG can be used to diagnose AIHA in patients whose autoantibody levels are too low to be detected by conventional DAT.
The diagnosis of autoimmune hemolytic anemia (AIHA) can be made with a stepwise approach that aims to identify laboratory and clinical evidence of hemolysis and then determine the immune nature of hemolysis with the direct anti-globulin test.
The indirect Coombs test looks for antibodies that are in the blood. These antibodies could act against certain red blood cells. This test is most often done to determine if you may have a reaction to a blood transfusion.
People with autoimmune hemolytic anemia don't have enough red blood cells because their body destroys them too soon. Indirect Coombs test tells your provider if there are antibodies present in your bloodstream that could attach to red blood cells.
3.1. Primary AIHA had a median survival of 9.8 years [95% CI: 8.73; 10.94] after diagnosis — much longer than secondary AIHA, where median survival was 3.3 years [95% CI: 2.93; 3.87].
The Coombs test checks your blood for antibodies that attack red blood cells. This test may be used to screen your blood before a procedure, such as a blood transfusion. Or, it may be used to find out if you have certain conditions, such as autoimmune hemolytic anemia.
Coombs test is necessary when autoimmunity to red blood cells is a consideration in the differential diagnosis, including warm and cold hemolytic anemia. Following are some indications where antiglobulin testing becomes useful: Autoimmune hemolytic anemia. Drug-induced immune hemolytic anemia.

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Entities that develop, deploy, or operate artificial intelligence systems that may impact safety, security, or compliance with regulatory requirements are typically required to file NTS AIHA.
Filling out NTS AIHA involves completing a structured form that includes sections for system identification, operational parameters, risk assessments, and compliance checks. Detailed documentation and supporting evidence must also be provided.
The information that must be reported includes system specifications, operational context, risk assessments, mitigation strategies, compliance with relevant laws, and outcomes of prior evaluations.
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