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SubmissionProofD:Dropbox(Compliance)2016OPERATIONS2016EDGAR03 MarchTargetedMedic... Page1of1 FORM4 UNITEDSTATESSECURITIESANDEXCHANGECOMMISSION Washington, D.C. 20549 STATEMENTOFCHANGESINBENEFICIALOWNERSHIP
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How to Fill Out 20549 Statement of Changes in Beneficial Ownership:

01
Obtain the required form: The 20549 Statement of Changes in Beneficial Ownership form can be obtained from the U.S. Securities and Exchange Commission (SEC) website or from other authorized sources.
02
Provide your personal information: Start by entering your name, address, phone number, and email address in the designated fields. This information will be used for contact purposes and to identify you as the filer.
03
Indicate the issuer and securities: Specify the name of the company whose securities you have a beneficial ownership interest in. Provide the ticker symbol or other identifying information. Include the type and class of the securities you own, such as common stock or preferred shares.
04
Fill in the transaction details: Report any changes in beneficial ownership that have occurred during the reporting period. This can include acquisitions, dispositions, or other transactions involving the securities. Enter the date, nature, and amount of each transaction.
05
Explain the transaction purpose: Provide a brief explanation of the purpose of the transaction. For example, if you acquired additional shares, mention whether it was for investment purposes or as part of a stock option exercise.
06
Disclose the ownership nature: Indicate whether the ownership interest is direct or indirect. If the interest is indirect, explain the relationship or entity through which the ownership is derived.
07
Provide additional information: If there is any additional information that is necessary for the proper understanding of the reported transactions or beneficial ownership, include it in the designated section.
08
Sign and date the form: Sign and date the form to acknowledge the accuracy and completeness of the information provided. Failure to sign the form may result in its rejection or non-compliance with SEC regulations.

Who Needs 20549 Statement of Changes in Beneficial Ownership:

01
Corporate insiders: Individuals who hold a senior position in a publicly traded company, such as officers, directors, and certain beneficial owners of more than 10% of the company's stock, are required to file the 20549 form to disclose their transactions and changes in beneficial ownership.
02
Issuers and their agents: Companies that have registered securities with the SEC and their designated agents or representatives are responsible for ensuring that the 20549 form is properly filed for any applicable individuals within their organization.
03
SEC regulatory compliance: The SEC requires the filing of the 20549 form as part of its regulatory oversight to promote transparency and safeguard the interests of investors. Filing this form helps to ensure compliance with federal securities laws and regulations.
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The 20549 statement of changes in beneficial ownership is a form that must be filed with the SEC to report any changes in ownership of securities by company insiders.
Company insiders, such as officers, directors, and certain shareholders, are required to file the 20549 statement of changes in beneficial ownership.
The form can be filled out electronically on the SEC's EDGAR system, providing details of the transaction, the security involved, and the relationship of the filer to the company.
The purpose of the form is to provide transparency to investors and regulators about changes in ownership of securities by company insiders.
The form requires reporting details of the security involved, the date of the transaction, the nature of ownership change, and the relationship of the filer to the company.
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