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The document provides information on the Direct Bilirubin assay for use on ARCHITECT c Systems™ and AEROSET System, including intended use, methodology, specimen handling, reagent information, quality
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How to fill out DIRECT BILIRUBIN

01
Obtain a clean container for urine or blood sample.
02
Label the container with patient details including name, date, and time of collection.
03
If it's a blood test, prepare the patient by explaining the procedure.
04
For blood, use a sterile needle to draw blood from a vein, and fill the collection tube.
05
For urine, instruct the patient on the proper method for collecting a midstream sample.
06
Store the sample in appropriate conditions until transport to the lab.
07
Complete and submit the laboratory requisition form, specifying the DIRECT BILIRUBIN test.

Who needs DIRECT BILIRUBIN?

01
Patients experiencing jaundice or unexplained liver abnormalities.
02
Individuals with suspected liver diseases such as hepatitis or cirrhosis.
03
Patients with hemolytic anemia or biliary obstruction.
04
Individuals undergoing routine liver function tests.
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Infant jaundice usually occurs because a baby's liver isn't mature enough to get rid of bilirubin in the bloodstream. In some babies, an underlying disease may cause infant jaundice. Most infants born between 35 weeks' gestation and full term need no treatment for jaundice.
Lower than usual bilirubin levels are usually not a concern. Higher levels of direct bilirubin in your blood may mean your liver isn't clearing bilirubin properly. This may mean there is liver damage or disease. Higher levels of indirect bilirubin may be a sign of other problems.
What are normal bilirubin levels in adults? Normal values of direct bilirubin range from 0 to 0.4 mg/dL. Total bilirubin (direct and indirect) ranges from about 0.2 to 1.2 mg/dL (some lab values range as high as 1.9 mg/dL). Medical literature sources have minor variations in "normal" levels.
High direct bilirubin indicates liver dysfunction or bile duct obstruction and requires treating the underlying cause through medical interventions, lifestyle changes, and regular monitoring. Treatment ranges from medications and procedures for blockages to dietary modifications and avoiding liver-damaging substances.
What level of bilirubin is concerning? Typically, adult bilirubin levels fall between 0.2 and 1.3 milligrams per deciliter (mg/dL). Anything above 1.3 mg/dL is usually considered elevated. For children ages 15 days to 18 years, healthy bilirubin levels should be less than 1.0 mg/dL.
On average, total bilirubin levels between 0.2 and 1.3 mg/dL are considered normal for children and adults. If your levels are higher, your healthcare provider may want to investigate further to look for the cause. It may suggest a problem that needs attention.
Bilirubin is not present in the of normal, healthy people. Results that are higher may mean that you have a liver problem, hepatitis, or gallstones. Higher levels may also mean that you have: A blood infection (called blood poisoning or septicemia).
2. Eat a Liver-Friendly Diet. Certain foods help detoxify the liver and reduce bilirubin: Fruits and vegetables like apples, beets, carrots, leafy greens, and citrus fruits.

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Direct bilirubin is a water-soluble form of bilirubin that is processed by the liver and can be excreted in urine. It is one of the two main types of bilirubin, the other being indirect bilirubin.
Direct bilirubin levels are typically tested in patients who may have liver or gallbladder issues. Medical professionals may order this test for individuals presenting with jaundice, abdominal pain, or other symptoms suggestive of liver dysfunction.
To perform a direct bilirubin test, a healthcare professional collects a blood sample, usually from a vein in the arm. The sample is then sent to a laboratory for analysis, where it is tested for direct bilirubin levels.
The purpose of measuring direct bilirubin is to diagnose and monitor liver and gallbladder disorders. Elevated levels may indicate conditions such as hepatitis, cirrhosis, or bile duct obstructions.
The report for a direct bilirubin test typically includes the measured concentration of direct bilirubin in the blood, reference ranges for normal levels, and any relevant notes from the laboratory regarding the sample or test results.
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