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Clinical Chemistry 47:4 661 666 (2001) Molecular Diagnostics and Genetics C677T and A1298C Polymorphisms of the Methylenetetrahydrofolate Reductase Gene: Incidence and Effect of Combined Genotypes
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C677T and A1298C are two common genetic polymorphisms in the MTHFR (methylenetetrahydrofolate reductase) gene. These polymorphisms can affect the function of the MTHFR enzyme, which plays a role in the metabolism of folate and homocysteine.
Filing c677T and A1298C polymorphisms is not a requirement. These polymorphisms are genetic variations that are often tested or reported in medical or genetic studies.
C677T and A1298C are not forms or documents that need to be filled out. They are genetic variations detected through genetic testing or analysis.
The purpose of studying C677T and A1298C polymorphisms is to understand genetic variations in the MTHFR gene that may impact health and disease risk, particularly in relation to folate metabolism and homocysteine levels.
When reporting C677T and A1298C polymorphisms, the information typically includes the specific genetic variation detected (e.g. homozygous, heterozygous), along with any relevant clinical implications or associations with particular health conditions.
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