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Targeting of Poly electrolyte RNA Complexes to Cell Surface Integrity as an Efficient, Cytoplasmic Transfection Mechanism ALAN PARKER AND LEONARD W. SEYMOUR* Cancer Research UK Institute for Cancer
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Here we show that Poly(?-caprolactone) (PEC) cationic polymer complexed to nucleosides allows delivery of RNA to the cell surface while maintaining expression of endogenous target genes. The RNA binding sites are located in the region of the RNA that is cleaved by poly(D)-oligonucleotide reductase (poly(D)NOR) to produce poly(D)-ribosylation products and in the region of the poly(A)-ribosylation product. The complex also reduces the degradation of the RNA by RNA polymerase. Poly(?-caprolactone) cationic polymer complexed to RNA in this way is a highly stable delivery system and was stable for 1 wk at 23 °C and 5 BC. Poly(?-caprolactone) may be used to treat cancer of the liver using an opsonized or soluble form of poly(?-caprolactone), in which case the RNA bound to the active complex can be released from the nanoparticle through either the mRNA or poly(?-caprolactone) by endocytosis into the extracellular fluid. This is the first demonstration of mRNA-mediated delivery of mRNA and establishes a new approach to gene therapy. Messenger RNA provides a promising alternative to plasmid DNA as a genetic material for delivery in non-viral gene therapy strategies. Here we show that Poly(?-caprolactone) (PEC) cationic polymer complexed to nucleosides allows delivery of RNA to the cell surface while maintaining expression of endogenous target genes. The RNA binding sites are located in the region of the RNA that is cleaved by poly(D)-oligonucleotide reductase (poly(D)NOR) to produce poly(D)-ribosylation products and in the region of the poly(A)-ribosylation product. The complex also reduces the degradation of the RNA by RNA polymerase. Poly(?-caprolactone) cationic polymer complexed to RNA in this way is a highly stable delivery system and was stable for 1 wk at 23 °C and 5 BC.

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Targeting of polyelectrolyte rna refers to the process of specifically delivering polyelectrolyte RNA molecules to a targeted cell or tissue in order to achieve a desired therapeutic effect.
The entities or individuals involved in the development, manufacture, or administration of polyelectrolyte RNA therapies are responsible for filing targeting of polyelectrolyte rna.
Filling out targeting of polyelectrolyte rna involves providing detailed information about the target cell or tissue, the delivery method, and the intended therapeutic goal. Specific forms or templates may be provided by regulatory authorities for this purpose.
The purpose of targeting of polyelectrolyte rna is to ensure that the therapy is delivered specifically to the desired cells or tissues, minimizing off-target effects and maximizing therapeutic efficacy.
The targeting of polyelectrolyte rna should include information such as the target cell or tissue, the delivery method, the specific polyelectrolyte RNA molecule used, and any relevant data supporting the effectiveness of the targeting strategy.
The specific deadline to file targeting of polyelectrolyte rna in 2023 may vary depending on the regulatory requirements of the jurisdiction. It is recommended to consult the relevant regulatory authority or seek legal advice for accurate and up-to-date information.
The penalty for the late filing of targeting of polyelectrolyte rna may also depend on the specific regulations and jurisdiction. Penalties could include financial penalties, delays in regulatory approvals, or other legal consequences. It is important to comply with filing deadlines to avoid potential penalties.
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