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This document serves as an addendum to the B6836 bid for the Juvenile Hall Detention Cell Door Replacement Project, providing clarifications, revised forms, and essential deadlines for the bidding
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Obtain a copy of Addendum #1 to B6836.
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Who needs Addendum #1 to B6836?

01
Individuals or entities that are required to provide additional information related to B6836.
02
Those who are part of the process outlined in B6836 that necessitates the submission of additional documentation.
03
Participants in a project or program related to B6836 that mandates this addendum.
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In November 2016, ICH released the first major update in 20 years to E6 Good Clinical Practice Guidelines. The addendum focuses on the implementation of technology to improve patient safety and the reliability of study data. The updated guideline is often referred to as ICH E6 R2.
The International Council for Harmonisation (ICH) E6 – good clinical practice (GCP) (R2) addendum – was released in 2016 to encourage implementation of improved approaches for the management of clinical trials.
The new ICH E6 integrated addendum (R2) requires sponsors to implement systems to manage quality throughout all stages of the trial process. The system should use a risk-based approach including which of the following? Identification of study risks to determine which may safely be omitted from continual monitoring.
Interpreting ICH E6(R3) In January 2025, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issued the final version of its updated ICH E6(R3) Good Clinical Practice Guideline.
What are the revisions? The focus of the revisions is on increasing human subject protections and data integrity mainly through better study design and conduct. Therefore, most of the changes affect the sponsor.
The new ICH E6 integrated addendum (R2) requires sponsors to implement systems to manage quality throughout all stages of the trial process. The system should use a risk-based approach including which of the following? Identification of study risks to determine which may safely be omitted from continual monitoring.
Key Changes in E6(R3) Greater emphasis on Quality Management Systems (QMSs) to ensure trial quality. Introduction of a “fit for purpose” approach to quality-by-design. Increased focus on study participants, considering their perspective in trial design and conduct.

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Addendum #1 to B6836 is a supplementary document that provides additional information and clarifications regarding the original B6836 form.
Individuals or entities that are involved in the process described in B6836 and need to provide additional details or updates must file Addendum #1.
To fill out Addendum #1 to B6836, you should carefully follow the instructions provided in the addendum, ensuring that all relevant sections are completed accurately and any supporting information is attached.
The purpose of Addendum #1 to B6836 is to supplement the original submission with essential updates or additional data required for compliance and review.
Addendum #1 to B6836 typically requires information such as updated data, clarifications, and any new developments that impact the content of the original B6836 form.
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