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This report by Families USA examines the spending and profit patterns of U.S. pharmaceutical companies, arguing against the industry's claim that high drug prices are primarily necessary for funding
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How to fill out Profiting from Pain: Where Prescription Drug Dollars Go

01
Begin with a clear understanding of the purpose of the document, which is to analyze and report on prescription drug spending.
02
Gather financial data related to prescription drug sales, including revenues and costs.
03
Identify key stakeholders in the pharmaceutical industry, such as manufacturers, retailers, and insurance companies.
04
Analyze the data to show where the majority of prescription drug dollars are allocated, such as research, marketing, and profits.
05
Present findings in a clear and organized manner, using charts or graphs to illustrate key points.
06
Write a summary highlighting the implications of the findings on public health and policy.
07
Edit and review the document for clarity, accuracy, and completeness before finalizing.

Who needs Profiting from Pain: Where Prescription Drug Dollars Go?

01
Healthcare professionals seeking to understand the financial dynamics of prescription drugs.
02
Policymakers looking to inform legislation related to pharmaceutical pricing and access.
03
Researchers studying the economic impact of prescription drugs on healthcare systems.
04
Consumers interested in understanding the costs associated with their medications.
05
Advocacy groups aiming to promote transparent pricing in the pharmaceutical industry.
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For the second year in a row, Merck's blockbuster PD-1 inhibitor Keytruda tops the list of pharma's best-selling products. In 2024, Keytruda surged 18% year-on-year to hit $29.48 billion in sales.
Here is our list of the 15 most profitable drugs in the world: Opdivo. Imbruvica. 2022 Sales: $8.35 billion. Stelara. 2022 Sales: $9.72 billion. Revlimid. 2022 Sales: $9.97 billion. Biktarvy. 2022 Sales: $10.39 billion. . 2022 Sales: $12.72 billion. Dupixent. 2022 Sales: $17.41 billion. . 2022 Sales: $18.26 billion.
In 2024, the global pharmaceutical market witnessed unprecedented growth, with the top-selling drugs collectively generating over $116 billion in revenue. Leading this surge was Merck's immuno-oncology therapy, Keytruda, which maintained its position as the world's best-selling drug with nearly $29.5 billion in sales.
Keytruda, a strong-selling cancer immunotherapy since the mid-2010s, maintained its position as the highest-grossing drug with sales of $25 billion, a 19% increase from 2022. Other oncology treatments, such as Darzalex, Opdivo, and Tagrisso, also experienced growth.
In 2022, U.S. prices across all drugs (brands and generics) were nearly 2.78 times as high as prices in the comparison countries. U.S. prices for brand drugs were at least 3.22 times as high as prices in the comparison countries, even after adjustments for estimated U.S. rebates.
. () Bristol Myers Squibb and Pfizer. 2024 Sales: $20.699 billion. Ozempic. (semaglutide) Novo Nordisk. 2024 Sales: $18.655 billion. Dupixent. (dupilumab)1 Sanofi and Regeneron Pharmaceuticals. 2024 Sales: $15.125 billion. Stelara (ustekinumab) Janssen Biotech (Johnson & Johnson) 2024 Sales: $10.361 billion.
First, the U.S. allows drug makers to set prices after FDA approval at any level they want, and then require Medicare and Medicaid to pay no matter what the drug's clinical utility. Second, we allow manufacturers to raise those prices each year beyond inflation.
Americans pay more for drugs than Europeans. Full stop. That is correct. The U.S. consistently pays the most in the world for many prescription drugs.

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Profiting from Pain: Where Prescription Drug Dollars Go is a report or documentation that tracks the financial flow associated with prescription drugs, focusing on how drug pricing and profits impact patients and the healthcare system.
Pharmaceutical companies, healthcare providers, and organizations that benefit from prescription drug sales may be required to file Profiting from Pain reports, depending on regulatory requirements in their jurisdiction.
To fill out the Profiting from Pain report, gather financial data related to prescription drug sales, including revenue, expenses, and pricing information, then complete the necessary forms or templates as provided by the regulatory authority.
The purpose of Profiting from Pain is to promote transparency in the pharmaceutical industry by detailing the financial aspects of drug pricing and helping to understand the economic pressures on patients and the healthcare system.
Reported information typically includes drug pricing, revenue generated from sales, marketing expenses, and any payments made to healthcare providers or institutions related to drug promotion.
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