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This semiannual publication provides information about immunization practices, updates on vaccine-preventable diseases, and recommendations for health professionals towards improving vaccination rates.
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Who needs Needle Tips and the Hepatitis B Coalition News?

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Healthcare professionals working with hepatitis B patients.
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Public health officials aiming to educate communities about hepatitis B.
03
Individuals living with hepatitis B or at risk for hepatitis B infection.
04
Researchers involved in hepatitis B studies.
05
Advocacy groups focused on hepatitis B awareness and prevention.
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The most recent candidate to enter clinical trials for hepatitis B is another therapeutic vaccine, known as TherVacB, after a first-in-human clinical trial was initiated for it on January 25, 2024. The vaccine has already gone through extensive preclinical testing, having progressed through 12 years of basic research.
Hepatitis B is also spread by needlestick injury, tattooing, piercing and exposure to infected blood and body fluids, such as saliva and menstrual, vaginal and seminal fluids.
In a recent paper published in Science Translational Medicine, scientists report that a class of drugs, called RNA interference (RNAi) therapeutics, represent a major advancement in the treatment of chronic HBV infections, expanding treatment strategies by addressing viral antigens, silencing the virus and helping to
A new chapter in hepatitis B treatment If successful, TherVacB could represent a breakthrough in the treatment of chronic hepatitis B. The ability to stimulate a functional immune response in already-infected patients could lay the groundwork for a true cure — something no existing therapy offers.
TherVacB, a therapeutic vaccine for chronic hepatitis B, has entered its first clinical trial in patients. The first patient was enrolled in June 2025 and treated with the vaccine. In a previous trial in healthy volunteers, the vaccine demonstrated a favorable safety profile and triggered the desired immune responses.
TherVacB, a therapeutic vaccine for chronic hepatitis B, has entered its first clinical trial in patients. The first patient was enrolled in June 2025 and treated with the vaccine. In a previous trial in healthy volunteers, the vaccine demonstrated a favorable safety profile and triggered the desired immune responses.
The U.S. Centers For Disease Control and Prevention (CDC) recommends screening all adults 18 and older for hepatitis B at least once in a lifetime. This recommendation complements the CDC's guidance to have all adults ages 19-59 vaccinated against hepatitis B.

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Needle Tips is a publication that provides information and updates on hepatitis B prevention, while the Hepatitis B Coalition News focuses on resources, advocacy, and community engagement for hepatitis B awareness and prevention.
Organizations, healthcare providers, and public health agencies involved in hepatitis B prevention and education are typically required to file Needle Tips and the Hepatitis B Coalition News.
To fill out Needle Tips and the Hepatitis B Coalition News, one must complete the required sections with accurate data on hepatitis B cases, prevention activities, and related news, following the provided guidelines for submission.
The purpose is to raise awareness about hepatitis B, share best practices for prevention, and foster collaboration among stakeholders in public health.
Reported information must include statistics on hepatitis B infections, details of prevention programs, community outreach efforts, and any relevant legislative or policy updates.
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