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Journal of Cell Science 112, 3549-3558 (1999) Printed in Great Britain The Company of Biologists Limited 1999 JCS0302 3549 Fibrillar assembly: dimer formation mediated by amino-terminal sequences
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How to fill out fibrillin forms extracellular dimers
01
To fill out fibrillin forms extracellular dimers, you need to understand the structure and function of fibrillin. Fibrillin is a glycoprotein that plays a crucial role in the formation of extracellular matrix and provides structural support to various tissues in the body.
02
The process of filling out fibrillin forms extracellular dimers involves the interaction of two fibrillin monomers to form a dimeric structure. This process is facilitated by specific domains within the fibrillin protein that allow the monomers to bind together.
03
To begin the process, it is important to have a sufficient amount of fibrillin monomers available. These monomers can be obtained from biological sources or produced synthetically using recombinant DNA technology.
04
Once the fibrillin monomers are obtained, they need to be purified to remove any impurities or contaminants. This can be done through various techniques such as chromatography or filtration.
05
After purification, the fibrillin monomers are mixed together in a controlled environment to allow for the formation of dimers. The conditions for this reaction may vary depending on factors such as pH, temperature, and the presence of any supporting molecules.
06
The formation of fibrillin extracellular dimers is crucial for the proper functioning of various tissues and organs in the body. Fibrillin plays a critical role in maintaining the elasticity and structural integrity of connective tissues, such as blood vessels, tendons, and skin.
07
Individuals who have mutations or deficiencies in fibrillin may develop medical conditions such as Marfan syndrome, a genetic disorder characterized by abnormalities in the connective tissues. In such cases, the proper formation of fibrillin extracellular dimers is essential for the prevention or management of these conditions.
08
In conclusion, the process of filling out fibrillin forms extracellular dimers involves understanding the structure of fibrillin, obtaining and purifying fibrillin monomers, and facilitating their interaction to form dimers. The proper formation of fibrillin extracellular dimers is important for maintaining the structural integrity and elasticity of various tissues, and individuals with fibrillin-related disorders may require specific interventions to ensure the formation of these dimers.
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What is fibrillin forms extracellular dimers?
Fibrillin forms extracellular dimers are proteins that bind together to form a mesh-like structure in the extracellular matrix.
Who is required to file fibrillin forms extracellular dimers?
There is no specific requirement for filing fibrillin forms extracellular dimers as they are naturally occurring proteins in the body.
How to fill out fibrillin forms extracellular dimers?
No action is required to fill out fibrillin forms extracellular dimers as they are formed naturally in the body.
What is the purpose of fibrillin forms extracellular dimers?
The purpose of fibrillin forms extracellular dimers is to provide structural support and elasticity to various tissues in the body, particularly in connective tissues like skin and blood vessels.
What information must be reported on fibrillin forms extracellular dimers?
No specific information needs to be reported as fibrillin forms extracellular dimers are naturally occurring proteins.
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