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Cancer-specific Genomic Instability in Bronchial Lavage: A Molecular Tool for Lung Cancer Detection Triantafillos Liloglou, Paul Maloney, George Icarians, et al. Cancer Res 2001;61:1624-1628. Updated
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Cancer-specific genomic instability refers to the presence of genetic alterations in the DNA of cancer cells that contribute to the development and progression of cancer. These alterations can include mutations, amplifications, deletions, rearrangements, and other genomic abnormalities.
Healthcare professionals and researchers involved in the diagnosis, treatment, and study of cancer are typically responsible for reporting and documenting cancer-specific genomic instability. This includes oncologists, geneticists, pathologists, and other individuals or institutions conducting genomic profiling and analysis of cancer cells.
Filling out a cancer-specific genomic instability report typically involves documenting the specific genomic alterations found in the cancer cells. This includes providing information on the specific genes or genomic regions affected, the type of alteration (e.g., mutation, amplification), and any associated clinical or research findings. The report may also include details on the methodology used for genomic analysis and interpretation, as well as any relevant patient or sample information.
The purpose of documenting and reporting cancer-specific genomic instability is to enhance understanding of the genetic drivers and mechanisms underlying cancer development and progression. It allows healthcare professionals and researchers to identify potential therapeutic targets, predict prognosis and response to treatment, and contribute to ongoing research efforts in precision medicine and cancer genomics.
The information typically reported on cancer-specific genomic instability includes details on the specific genomic alterations identified, such as gene mutations, copy number variations, chromosomal rearrangements, and other abnormalities. Additional information may include clinical or research context, such as tumor type, patient characteristics, treatment history, and relevant laboratory methodologies used for genomic profiling and analysis.
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