Get the free Direct reductive amination of aldehydes with nitroarenes - surfcat fudan edu

Green Chemistry View Article Online Published on 16 December 2015. Downloaded by Sudan University on 20×04/2016 04:30:44. PAPER Cite this: Green Chem., 2016, 18, 2507 View Journal View Issue Direct

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How to Fill Out Direct Reductive Amination of:

1. Gather all necessary materials and reagents for the reaction, including the amine starting material, aldehyde or ketone starting material, reducing agent (such as sodium cyanoborohydride or sodium triacetoxyborohydride), solvent (typically a polar aprotic solvent like DMF or DMSO), acid catalyst (such as acetic acid), and any other additives or catalysts required for the specific reaction conditions.
2. Prepare a reaction vessel, typically a round-bottom flask or a reaction tube, ensuring that it is clean and dry.
3. Add the amine starting material and the aldehyde or ketone starting material to the reaction vessel in the desired stoichiometric ratio. The amine and carbonyl reactants can be added separately or as a pre-formed imine via condensation, depending on the specific reaction conditions.
4. Add the reducing agent to the reaction mixture. The reducing agent will convert the imine intermediate into the amine product through the process of reductive amination.
5. Add the acid catalyst and any other required additives or catalysts to the reaction mixture. The acid catalyst helps facilitate the reaction by promoting protonation and facilitating the transfer of hydride from the reducing agent to the imine intermediate. Other additives or catalysts may be necessary depending on the specific reaction conditions.
6. Add the solvent to the reaction mixture, ensuring that all components are well mixed and homogeneous.
7. Stir the reaction mixture at the appropriate temperature for the specified reaction time. The temperature and reaction time will vary depending on the specific reactants and desired reaction conditions.
8. After the reaction is complete, quench the reaction by adding a suitable quenching agent, such as water or a weak acid, to stop the reaction and neutralize any excess acid catalyst.
9. The resulting product can be isolated and purified using various techniques, such as extraction, distillation, crystallization, or chromatography, depending on the nature of the product and desired purity level.

Who needs direct reductive amination of:

1. Organic chemists and researchers involved in synthetic chemistry or medicinal chemistry may need to use direct reductive amination as a method to synthesize or modify organic compounds. This reaction is particularly useful for the synthesis of amines, which are prevalent in many biologically active molecules and pharmaceuticals.
2. Industries involved in the production of fine chemicals, pharmaceuticals, agrochemicals, and other organic compounds may also require direct reductive amination as a synthetic tool.
3. Students and educators in chemistry-related fields may need to understand and learn about direct reductive amination as part of their curriculum or research studies. This reaction is commonly taught in organic chemistry courses and is an important tool in the toolbox of synthetic chemists.

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What is direct reductive amination of?

Direct reductive amination is a synthetic method used in organic chemistry to convert ketones or aldehydes into amines.

Who is required to file direct reductive amination of?

Direct reductive amination is a laboratory procedure and does not require filing.

How to fill out direct reductive amination of?

There is no form or paperwork to fill out for direct reductive amination as it is a chemical reaction process.

What is the purpose of direct reductive amination of?

The purpose of direct reductive amination is to form a carbon-nitrogen bond in organic molecules.

What information must be reported on direct reductive amination of?

No information needs to be reported for direct reductive amination as it is a chemical process carried out in a laboratory.

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