Fillable Applications of the human p53 knock-in (Hupki) mouse model for ... - fasebj

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The FASEB Journal Review Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing Ahmad Besaratinia1 and Gerd P. Pfeifer Department of Cancer Biology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, California, USA Tumor-driving mutations in the TP53 gene occur frequently in human cancers. These inactivating mutations arise predominantly from a...
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