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Pro. Natl. Acid. Sci. USA Vol. 74, No. 5, pp. 1965-1968, May 1977 Biochemistry Role of DNA gyrate in OX replicative-form replication in vitro (DNA gyrate/super twisted OX replication form/ X gene
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How to fill out role of dna gyrase
01
To fill out the role of DNA gyrase, one must first understand its function. DNA gyrase is an enzyme that plays a crucial role in DNA replication and maintenance. It is responsible for introducing negative supercoiling into the DNA molecule, which helps to relieve torsional stress caused by unwinding during replication.
02
To fully understand and fill out the role of DNA gyrase, it is important to explore its mechanism of action. This enzyme binds to DNA and introduces a double-stranded break in one of the DNA strands. It then passes another segment of the DNA molecule through this break, effectively causing the DNA to become negatively supercoiled. This process is crucial for proper DNA replication and transcription.
03
Understanding the targets and inhibitors of DNA gyrase is another aspect of filling out its role. DNA gyrase is found in bacteria and some other organisms, but not in humans. Therefore, it has been a target for various antibiotics, such as fluoroquinolones, which specifically target this enzyme in bacteria. By inhibiting DNA gyrase, these antibiotics disrupt DNA replication and cause bacterial cell death.
04
Another important aspect of filling out the role of DNA gyrase is the evolutionary significance of this enzyme. Despite its absence in humans, DNA gyrase is highly conserved in bacteria and plays a vital role in their survival. It is involved in processes such as DNA repair, recombination, and regulation of gene expression. Understanding the importance of DNA gyrase in bacterial physiology helps to appreciate its role and the potential for developing novel antibacterial strategies.
Now, let's move on to the second part of the question.
Who needs the role of DNA gyrase?
01
Bacteria heavily rely on DNA gyrase for their normal cellular functions. Without DNA gyrase, bacteria would struggle to maintain the structural integrity and stability of their DNA molecules during replication and transcription processes.
02
The role of DNA gyrase is especially crucial for bacterial pathogenicity. Many bacterial pathogens, including those responsible for infections such as pneumonia, urinary tract infections, and food poisoning, rely on DNA gyrase for their survival and proliferation within the human body.
03
Researchers and clinicians studying bacterial infections and developing antimicrobial therapies also need to understand the role of DNA gyrase. By targeting DNA gyrase with specific inhibitors, they can disrupt bacterial replication and effectively treat bacterial infections.
In summary, understanding and filling out the role of DNA gyrase is important for researchers, clinicians, and anyone interested in bacteria, DNA replication, and antimicrobial therapies. Its function in DNA replication, mechanisms of action, targets, and evolutionary significance provide valuable insights into the biology of bacteria and potential strategies for combating bacterial infections.
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What is role of dna gyrase?
DNA gyrase is an enzyme that is responsible for the supercoiling of DNA during DNA replication and transcription in bacteria.
Who is required to file role of dna gyrase?
The role of DNA gyrase is a scientific concept and does not require any specific filing.
How to fill out role of dna gyrase?
The role of DNA gyrase is not something that can be filled out as it is a biological function.
What is the purpose of role of dna gyrase?
The purpose of DNA gyrase is to provide the necessary tension and twist in the DNA molecule for efficient replication and transcription in bacteria.
What information must be reported on role of dna gyrase?
There is no specific information that needs to be reported on the role of DNA gyrase as it is a scientific concept.
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