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Pro. NATO. Acid. Sci. USA Vol. 76, No. 6, pp. 2674-2678, June 1979 Biochemistry Noncovalent intermolecular cross-links are produced by reaction with duplex DNA (covalently closed circular DNA/DNA-reactive
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01
Noncovalent intermolecular crosslinks can be filled out by carefully selecting and positioning molecules or functional groups that have the potential to form noncovalent interactions. These interactions can include hydrogen bonding, electrostatic interactions, van der Waals forces, or hydrophobic interactions.
02
It is important to consider the appropriate solvents or conditions under which these noncovalent interactions can occur. This may involve optimizing the pH, temperature, or concentration of the components to facilitate the formation of crosslinks.
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Techniques such as crystallization, self-assembly, or covalent binding can be employed to help guide and stabilize the formation of noncovalent intermolecular crosslinks.
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Researchers in the field of materials science may utilize noncovalent intermolecular crosslinks to create novel materials with specific properties. By engineering these crosslinks, they can control the mechanical, thermal, and optical characteristics of the materials, making them suitable for various applications such as drug delivery systems, tissue engineering scaffolds, or flexible electronics.
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In the field of chemistry, noncovalent intermolecular crosslinks are important for understanding molecular recognition, protein-ligand interactions, or supramolecular chemistry. These interactions are crucial for various biological processes, such as enzyme-substrate binding or DNA-protein interactions.
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Additionally, the pharmaceutical industry can benefit from noncovalent intermolecular crosslinks. By designing drugs that target specific molecular receptors through noncovalent interactions, drug efficacy and selectivity can be enhanced, leading to improved therapeutic outcomes and reduced side effects.
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