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Functional classification of -stimulated genes identified using microarrays Michael J. DE Veer, * Michelle Hold, *?, Mathias Revel, * Eldon Walker, Sandy Her, Jayashree M. Paragraph, * Robert H. Silverman,
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Start by identifying the specific goals or objectives of the stimulation.
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Assess the different functional areas that will be involved or impacted by the stimulation.
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Assign a classification label or category to each functional area based on its role or purpose in the stimulation.
Who needs functional classification of stimulated?
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Researchers or scientists conducting studies or experiments involving stimulation techniques.
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Note: The specific individuals or organizations who need functional classification of stimulated may vary depending on the context or field of application.
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How is interferon-stimulated?
Virus entry triggers cellular pathogen sensors, which induce production of IFN and IFN regulatory factor 3 (IRF)-dependent genes. Type I IFN is secreted and binds to IFN-α receptor on the same and neighboring cells, activating production of a wider array of IFN-stimulated genes (ISGs).
What do interferon-stimulated genes do?
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production.
What are the functions of interferon stimulated genes?
Interferon stimulated genes can act as an initial response to pathogen invasion, slowing down viral replication and increasing expression of immune signaling complexes. There are three known types of interferon. With approximately 450 genes highly expressed in response to interferon type I.
Where are type 1 interferons produced?
Innate immune cells, such as macrophages and dendritic cells (DCs), produce type I IFNs after sensing pathogen components using various pattern-recognition receptors (PRRs), which are found on the plasma membrane, in endosomes and throughout the cytosol.
How do interferons activate genes?
Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades.
What is an example of an interferon stimulated gene?
The IFN response uses several ISG effectors to directly degrade viral RNAs or viral genomes, thereby potently suppressing viral replication. The most well-studied examples are the oligoadenylate synthetases (OAS proteins), ZAP, and interferon-stimulated gene 20 (ISG20).
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What is functional classification of stimulated?
Functional classification of stimulated refers to the categorization of activities or processes based on their primary function or purpose in a specific context.
Who is required to file functional classification of stimulated?
The entity or individual responsible for conducting or overseeing the activities or processes being stimulated is typically required to file the functional classification.
How to fill out functional classification of stimulated?
The functional classification of stimulated is typically filled out by providing detailed information about the activities or processes being stimulated, their intended function, and any relevant supporting documentation.
What is the purpose of functional classification of stimulated?
The purpose of functional classification of stimulated is to provide a systematic and standardized way of categorizing and analyzing the activities or processes being stimulated, which helps in understanding their impact and effectiveness.
What information must be reported on functional classification of stimulated?
The information that must be reported on the functional classification of stimulated includes the description of the activities or processes being stimulated, their primary function, the expected outcomes, and any relevant supporting information or documentation.
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