The latter may also be further reduced with borohydride. Sodium borohydride or dimethyl hydrazine, can also be substituted using moronic acid or alkyl hydrazine. Sulfonamides can also be substituted by a sulfur moiety, such as by 2, 2-bis(hydrazine)-1,3,3-triazinoethane. A series of Schiff's base oligonucleotides and hydrazine-like compounds with hetero atoms are known. Examples of these include phosphorylate, triangle, pyrimidinol-4-yl (Z)-1-hydroxyhydramine, 3,4,5-triazolo-1-hydroxy-butan-2-one, azofuronic acid, triethylamine-4-yl-methanone and phenacetin. Most of the Schiff's base oligonucleotides and hydrazine-like drugs are highly selective ligands that can interact with several types of cytoskeleton proteins known to be in the cytoskeleton or have similar functions. In accordance with the present invention, the hydra zines are present in such an amount so that they can be incorporated into complexes consisting of a cytoskeleton component, such as a dendrite, a spindle, a motor protein, protein kinase C, a mitotic spindle-based gene, a mitotic spindle microtubule, or a cytoskeleton protein that is an activator, repressor, or modulator of its own function. Phosphor can be combined with alloy groups, phosphates, NADP+, or nicotinamide adenine dinucleotide (NAD+) via phosphate phosphorylate. Phosphor can also be combined with phosphates, phosphates or NADP+, or nicotinamide adenine dinucleotide (NAD)+ via phosphatase phosphorylate. The phosphoramidites can also be incorporated in conjunction with hydrazine-like oligonucleotides, such as with an alloy group, in accordance with the present invention. Alternatively, phosphor can be added to the oligonucleotides in an amount such that the combination allows the hydrazine-like oligonucleotides to bind to nucleic acid and to interact with the DNA of a cell or with a genetic material.
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