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Application Note: TI-OL05-0908 Phosphothioate Oligonucleotide (PTO) Description Oligonucleotides with one sulfur atom replacing oxygen in the inter-nucleotidic linkage Base HO CH2 H H O H Base S P OH H O H Base S P OH H OH H O CH2 H O H H O O CH2 H O H H O O H H O Full PTOs are more stable than "thio-cap" oligonucleotides, but due to their extreme stability and their hydrophobic character they can also...
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pto oligonucleotides
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