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Dr. Andy Baxevanis: Okay, good morning everyone, and thank you for joining us on this absolutely beautiful day here on the Bethesda Campus. Our lecture today is devoted to genome-wide association studies. And as you all know, these kinds of studies really help us separate genetic variations that are biologically insignificant from those that do produce some sort of change that might ultimately be detrimental or advantageous to a particular individual. And study of these variations are also critical to identifying what genes are responsible for particular genetic or genomic disorder as you heard about during last week's lecture by Lynn Jorge. There's also a much more practical reason to study these genetic variations, particularly the single nuclear type polymorphisms or SNPs that give rise to all of those subtle differences between each one of us in this hall since a very thorough understanding of these variations might provide a way for us to know in advance how well someone will respond to particular drug or to a particular treatment regimen. And we'll hear much more about thepharmacogenomic implications of having this kind of knowledge in next week's lecture in this hall by Howard McLeod. This week I am very pleased to introduce to you Dr. Karen Mole, who will be presenting today's lecture on genome-wide association studies. Dr. Mole is an NH GRI alumna, having done her post-doctoral work in Francis Collins' lab where she used genome-wide approaches to localize diabetes susceptibility genes. She is currently an associate professor in the Department of Genetics at the University of North Carolina, a member of the CarolinaCenter for Genome Sciences, and a member of the Linebacker Comprehensive Cancer Center at UNC. Her lab studies complex traits with complex inheritance patterns using many of the approaches that she will be describing to you today to study conditions such as type2 diabetes and obesity. As always, it's a pleasure to have you here with us today, Karen. And, so please join me in welcoming Dr. Karen Mole back to the NIH campus. Okay. Applause Dr. Karen Mole: All right. All right, thank you very much. It's always a pleasure to be here, and no, no difference. It's always a pleasure to behead. So, as Andy said, I'm going to be talking today about genome-wide association studies, and these are especially relevant for complex traits. Oh. And I have no relevant financial relationships to describe. So, complex traits are traits that have both genetic and environmental contributions' totem. There may be many genetic factors, many environmental factors, and these factors may interact. That is, that there's not necessarily a single gene responsible for these traits. And some genetic factors have rather subtle effects. As we investigate genome-wide association studies, these are especially good at identifying common genetic factors that may be responsible for common variation in complex traits. Andy common factors I mean that when looking at...
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