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& (19) (11) EP 2 154 137 A1 EUROPEAN PATENT APPLICATION (12) (43) Date of publication: (51) Int Cl.: C07D 471/04 (2006.01) A61P 31/04 (2006.01) 17.02.2010 Bulletin 2010/07 A61K 31/437 (2006.01) (21)
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How to fill out crystalline form of base:

01
Prepare the necessary materials and equipment. This may include the base substance, a balance or weighing scale, a mortar and pestle, a sieve or filter, and a container for mixing.
02
Weigh the desired amount of base substance using a balance or weighing scale. It is important to accurately measure the amount to ensure consistency in the crystalline form.
03
If the base substance is in a solid form, grind it using a mortar and pestle to create a fine powder. This will help with better dissolution and crystal formation.
04
If the base substance contains impurities or unwanted particles, sieve or filter it to remove any debris or foreign matter. This will result in a purer crystalline form.
05
In a separate container, dissolve the base substance in a suitable solvent. The type of solvent will depend on the specific base substance being used. It is important to follow the recommended guidelines for dissolution.
06
Mix the solvent and base substance thoroughly to ensure complete dissolution. This can be done by stirring or shaking the container gently.
07
Once the base substance is fully dissolved, allow the solution to cool down slowly. This will aid in the formation of well-defined crystals.
08
After the solution has cooled, crystals should start forming. Carefully collect the crystals using a filter or sieve. Rinse them with a small amount of the same solvent to remove any impurities.
09
Allow the collected crystals to dry in a controlled environment. This could be done by placing them on a clean surface or using a desiccator. Avoid exposure to direct sunlight or excessive heat, as this may affect the crystal structure.
10
Once the crystals are completely dry, they can be stored in a suitable container for future use or analysis.

Who needs crystalline form of base?

01
Chemists and researchers studying the properties and behavior of the base substance may require the crystalline form for more accurate analysis and experimentation.
02
Pharmaceutical companies may need the crystalline form of a base substance to evaluate its purity, stability, and efficacy for drug formulation.
03
Manufacturers involved in the production of various products, such as cosmetics, pigments, dyes, or catalysts, may use the crystalline form of a base substance in their manufacturing processes to ensure consistent quality and performance.
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Crystalline form of base refers to the physical form in which a chemical compound exists in a solid state with a highly ordered arrangement of molecules.
The manufacturer or distributor of the chemical compound is typically required to file the crystalline form of base.
The crystalline form of base is typically filled out using a specific form provided by regulatory authorities, which requires information about the compound's molecular structure and physical properties.
The purpose of crystalline form of base is to accurately document the structure and properties of a chemical compound, which is essential for regulatory compliance and intellectual property protection.
The crystalline form of base report typically includes details such as the compound's chemical formula, molecular weight, crystal structure, melting point, and any other relevant physical properties.
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