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OMB Number: 4040004 Expiration Date: 08/31/2016 APPLICATION FOR FEDERAL ASSISTANCE SF424 1. Type of Submission: Version 02 2. Type of Application: Reapplication New Application X If Revision, select
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Integration site preference topics refer to the specific locations within a genome where a viral vector integrates during gene therapy.
Researchers and scientists working on gene therapy studies are required to file integration site preference topics.
Integration site preference topics can be filled out by providing detailed information about the genomic locations where viral vectors integrate.
The purpose of integration site preference topics is to document and analyze the integration sites of viral vectors used in gene therapy to understand potential risks and improve safety.
Information such as the specific genomic locations, frequency of integration, and any potential gene disruptions must be reported on integration site preference topics.
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