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To overcome this problem I will measure tonic A1 receptor-dependent inhibition at the CA3-CA1 synapse in hippocampal slices and use to quantify the level of adenosine at the synapse. To measure synaptic adenosine mediated inhibition 200 nM 8-cyclopentyl-1 3-dimethylxanthine CPT an adenosine A1 receptor selective antagonist will be applied for thirty minutes. The increase in field potential slope produced following relief of inhibition by this drug will be taken as a measure of adenosine tone...
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The outline for neuroscience student is a document outlining the courses, research projects, and other requirements that must be completed in order to graduate with a degree in neuroscience.
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