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T1/2 25 hrs alone 13 hrs with enzyme inducing AEDs PB PHT CBZ PRM oral contraceptives or 70 hrs with inhibitor valproate. SANAD-A Retention SANAD--A Seizure Control SANAD Probabilityy of 12month remission staying on-drug N 1721 Years from randomization Recommended AEDs for Focal Seizures Generalized-onset Epilepsy Monotherapy First valproate none vastly superior Second phenobarbital Third Adjunctive therapy only N 716 First ezogabine Second Less effective Based on ILAE Treatment Guidelines...
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