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5 Washington D.C. 20549 First 2. Issuer Name and Ticker or Trading Symbol OPKO Health Inc. OPK Middle 5. Title of Security Instr 3. 2. Transaction 2A. Deemed Date Execution Code MM/DD/YYYY Date if any Instr. 8 V 4. Additional Reporting Owners Name Address Frost Gamma Investments Trust 4400 Biscayne Blvd. Miami FL 33137 CIK 0001380896 Relationship 10 Owner JOINT FILER INFORMATION Name Frost Gamma Investments Trust Designated Filer Phillip Frost M. Ownership 7. Nature of Indirect Form Direct D...

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