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In addition expression of the CXCR4 receptor in FLT3 mutated AML is also correlated with poor outcomes. Accordingly it is believed that inhibition of CXCR4 may sensitize AML cells toward chemotherapy and FLT-3 targeted therapies. Both CXCL12 and its receptor CXCR4 are key players in enabling AML cancer cells to hide and thrive in the bone marrow and CXCR4 expression in AML patients is associated with poor prognosis. FLT3 mutations are detected in approximately 30 of AML cases and are...
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