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The ranges of individual values of Cmax AUC72h AUClast and AUC for TMC207 largely overlapped for both subject groups Figure 16. Based on simulation of the pharmacokinetics of TMC207 in 2000 subjects using the population AUC24h of approximately 23 g. Validation characteristics for the bioanalytical methods for determination of TMC207 and M2 in plasma are the analysis of TMC207 and M2 in sputum homogenate samples. Phospholipidosis has been observed following administration of TMC207 and M2 in...

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