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REVIEW455Development 139, 455464 (2012) DOI:10.1242/dev.061838 2012. Published by The Company of Biologists Regulation of DNA replication during development Jared Norman and Terry L. Orr Weaver×As
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01
Step 1: Start by understanding the basic process of DNA replication. DNA replication is a crucial step in cell division, where the genetic information in the DNA molecule is copied to produce two identical DNA molecules.
02
Step 2: Familiarize yourself with the key components involved in DNA replication. These include DNA polymerases, DNA helicase, DNA primase, and DNA ligase.
03
Step 3: Begin by unwinding the DNA molecule using DNA helicase. This enzyme breaks the hydrogen bonds between the two DNA strands, separating them and creating a replication fork.
04
Step 4: Use DNA primase to add a short RNA primer to the single-stranded DNA template. This primer serves as a starting point for DNA polymerase to begin synthesis.
05
Step 5: DNA polymerase then extends the RNA primer by adding complementary nucleotides to the growing DNA strand. It proceeds in the 5' to 3' direction, synthesizing one new leading strand and one lagging strand in a discontinuous manner.
06
Step 6: As the DNA polymerase extends the lagging strand, it creates short DNA fragments called Okazaki fragments. These fragments are later joined together by DNA ligase.
07
Step 7: Once the synthesis of the leading and lagging strands is complete, proofreading mechanisms ensure the accuracy of the newly synthesized DNA molecules.
08
Step 8: Finally, the replicated DNA molecules are fully formed and can be used for various cellular processes or passed on to daughter cells during cell division.
Who needs regulation of dna replication?
01
DNA replication regulation is essential for all living organisms that undergo cell division.
02
It is vital for maintaining genomic stability and preventing mutations during DNA replication.
03
Cells with damaged DNA or those undergoing stressful conditions often require regulation of DNA replication to ensure proper repair and maintenance.
04
Developmental processes, such as embryogenesis, also rely on precise regulation of DNA replication to ensure the proper growth and differentiation of cells.
05
Additionally, regulation of DNA replication is crucial in cancer cells, as uncontrolled and aberrant DNA replication can lead to genomic instability and tumor progression.
06
Moreover, organisms with complex genetic systems, such as humans, require precise regulation of DNA replication to maintain the integrity and fidelity of genetic information.
07
In summary, regulation of DNA replication is fundamental for the proper functioning and survival of all organisms, playing a critical role in maintaining genetic stability and cellular homeostasis.
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What is regulation of dna replication?
Regulation of DNA replication refers to the control mechanisms that ensure the accurate and timely duplication of a cell's genetic material.
Who is required to file regulation of dna replication?
Regulation of DNA replication is typically studied and understood by researchers in the fields of molecular biology and genetics.
How to fill out regulation of dna replication?
Regulation of DNA replication can be studied through various experimental techniques and molecular biology tools.
What is the purpose of regulation of dna replication?
The purpose of regulation of DNA replication is to ensure that genetic information is accurately copied and transmitted to new cells during cell division.
What information must be reported on regulation of dna replication?
The information reported on regulation of DNA replication may include details about the proteins and enzymes involved in the replication process, as well as any regulatory factors that control the timing and accuracy of replication.
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