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BBC Papers in Press. Published on March 29, 2005, as Manuscript M502769200Presenilin1 D257A and D385A mutants fail to cleave Notch in their endoproteolysed forms, but only Presenilin1 D385A mutant

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Presenilin-1 d257a and d385a are genetic mutations in the presenilin-1 gene which are associated with early-onset Alzheimer's disease.

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